Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2519043..2520631 | Replicon | chromosome |
Accession | NZ_CP082772 | ||
Organism | Escherichia coli O2:H1 strain HM670 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A1L1KDK2 |
Locus tag | K8B93_RS12210 | Protein ID | WP_001125431.1 |
Coordinates | 2519043..2520365 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | V0VAH2 |
Locus tag | K8B93_RS12215 | Protein ID | WP_001304368.1 |
Coordinates | 2520365..2520631 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8B93_RS12190 (2516393) | 2516393..2517103 | - | 711 | WP_001195181.1 | fimbria/pilus periplasmic chaperone | - |
K8B93_RS12195 (2517108) | 2517108..2517593 | - | 486 | Protein_2368 | SDR family oxidoreductase | - |
K8B93_RS12200 (2517742) | 2517742..2518323 | + | 582 | Protein_2369 | LysR family transcriptional regulator | - |
K8B93_RS12205 (2518326) | 2518326..2518733 | + | 408 | Protein_2370 | acetylxylan esterase | - |
K8B93_RS12210 (2519043) | 2519043..2520365 | - | 1323 | WP_001125431.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
K8B93_RS12215 (2520365) | 2520365..2520631 | - | 267 | WP_001304368.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
K8B93_RS12220 (2520939) | 2520939..2521697 | + | 759 | WP_001286540.1 | trans-aconitate 2-methyltransferase | - |
K8B93_RS12225 (2521701) | 2521701..2522615 | - | 915 | WP_001443133.1 | bestrophin family protein | - |
K8B93_RS12230 (2522812) | 2522812..2524263 | - | 1452 | WP_000854660.1 | tagaturonate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 2505682..2520631 | 14949 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49310.02 Da Isoelectric Point: 8.6972
>T214865 WP_001125431.1 NZ_CP082772:c2520365-2519043 [Escherichia coli O2:H1]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKNSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKNSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
>T214865 NZ_CP110296:c3080288-3079974 [Xanthomonas citri pv. fuscans]
ATGATCTTCGTCGAGACCCCCATCTTCACTGCCTCGGTGACAGAGCTTTTGACCGATGAGCAGTACGGGGCGTTTCAGTC
ATTCCTGATCGCGGAGCCGCGCGCCGGCGACGTCATCGAGCAGACGGGCGGCCTGCGTAAGGTGCGCTGGTCTGTAGCGG
GGAAGGGCAAGCGCGGCGGGGTCAGGGTTATCTACTACTTCGTGGATGAGGCCGATCAGATCCGGCTGCTGCTGATCTAC
AAAAAGGGCGTGCAGGACGACCTGACGCCGTCCCAGAAGAAAGTGCTGAAAGCAATCAAAGACGGGTGGGCATGA
ATGATCTTCGTCGAGACCCCCATCTTCACTGCCTCGGTGACAGAGCTTTTGACCGATGAGCAGTACGGGGCGTTTCAGTC
ATTCCTGATCGCGGAGCCGCGCGCCGGCGACGTCATCGAGCAGACGGGCGGCCTGCGTAAGGTGCGCTGGTCTGTAGCGG
GGAAGGGCAAGCGCGGCGGGGTCAGGGTTATCTACTACTTCGTGGATGAGGCCGATCAGATCCGGCTGCTGCTGATCTAC
AAAAAGGGCGTGCAGGACGACCTGACGCCGTCCCAGAAGAAAGTGCTGAAAGCAATCAAAGACGGGTGGGCATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9957.31 Da Isoelectric Point: 4.9632
>AT214865 WP_001304368.1 NZ_CP082772:c2520631-2520365 [Escherichia coli O2:H1]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW
Download Length: 267 bp
>AT214865 NZ_CP110296:c3079974-3079684 [Xanthomonas citri pv. fuscans]
ATGGACAAGAATCTCTTCGCACAACTCGCCGAGAGCATGGAACAGATGGGCGAGATCACTCGCGGCGAACGGGCTCCGTC
TCGCGAGATCCACATCGATGCCGTGCGGGTGAAAGAGGTCCGGGCCGCCACTGGGCTGTCACAGGCGAAATTCGCTCAGG
TGATCGACGTGCAGCTCGGCACCTTGCGTAATTGGGAGCAGGGGCGGCGGAACCCTACGGGGCCTGCCCGAGCGCTGCTG
CGTGCGATCAAGAAGGATCCCAAGAGCGTGCTGGAAGCTCTGTCAGCCTGA
ATGGACAAGAATCTCTTCGCACAACTCGCCGAGAGCATGGAACAGATGGGCGAGATCACTCGCGGCGAACGGGCTCCGTC
TCGCGAGATCCACATCGATGCCGTGCGGGTGAAAGAGGTCCGGGCCGCCACTGGGCTGTCACAGGCGAAATTCGCTCAGG
TGATCGACGTGCAGCTCGGCACCTTGCGTAATTGGGAGCAGGGGCGGCGGAACCCTACGGGGCCTGCCCGAGCGCTGCTG
CGTGCGATCAAGAAGGATCCCAAGAGCGTGCTGGAAGCTCTGTCAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1L1KDK2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0VAH2 |