214865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2519043..2520631 Replicon chromosome
Accession NZ_CP082772
Organism Escherichia coli O2:H1 strain HM670

Toxin (Protein)


Gene name hipA Uniprot ID A0A1L1KDK2
Locus tag K8B93_RS12210 Protein ID WP_001125431.1
Coordinates 2519043..2520365 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V0VAH2
Locus tag K8B93_RS12215 Protein ID WP_001304368.1
Coordinates 2520365..2520631 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B93_RS12190 (2516393) 2516393..2517103 - 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -
K8B93_RS12195 (2517108) 2517108..2517593 - 486 Protein_2368 SDR family oxidoreductase -
K8B93_RS12200 (2517742) 2517742..2518323 + 582 Protein_2369 LysR family transcriptional regulator -
K8B93_RS12205 (2518326) 2518326..2518733 + 408 Protein_2370 acetylxylan esterase -
K8B93_RS12210 (2519043) 2519043..2520365 - 1323 WP_001125431.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
K8B93_RS12215 (2520365) 2520365..2520631 - 267 WP_001304368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K8B93_RS12220 (2520939) 2520939..2521697 + 759 WP_001286540.1 trans-aconitate 2-methyltransferase -
K8B93_RS12225 (2521701) 2521701..2522615 - 915 WP_001443133.1 bestrophin family protein -
K8B93_RS12230 (2522812) 2522812..2524263 - 1452 WP_000854660.1 tagaturonate reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2505682..2520631 14949


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-103)

Antitoxin

(14-69)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49310.02 Da        Isoelectric Point: 8.6972

>T214865 WP_001125431.1 NZ_CP082772:c2520365-2519043 [Escherichia coli O2:H1]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKNSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T214865 NZ_CP110296:c3080288-3079974 [Xanthomonas citri pv. fuscans]
ATGATCTTCGTCGAGACCCCCATCTTCACTGCCTCGGTGACAGAGCTTTTGACCGATGAGCAGTACGGGGCGTTTCAGTC
ATTCCTGATCGCGGAGCCGCGCGCCGGCGACGTCATCGAGCAGACGGGCGGCCTGCGTAAGGTGCGCTGGTCTGTAGCGG
GGAAGGGCAAGCGCGGCGGGGTCAGGGTTATCTACTACTTCGTGGATGAGGCCGATCAGATCCGGCTGCTGCTGATCTAC
AAAAAGGGCGTGCAGGACGACCTGACGCCGTCCCAGAAGAAAGTGCTGAAAGCAATCAAAGACGGGTGGGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9957.31 Da        Isoelectric Point: 4.9632

>AT214865 WP_001304368.1 NZ_CP082772:c2520631-2520365 [Escherichia coli O2:H1]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
AEQQDLEW

Download         Length: 267 bp

>AT214865 NZ_CP110296:c3079974-3079684 [Xanthomonas citri pv. fuscans]
ATGGACAAGAATCTCTTCGCACAACTCGCCGAGAGCATGGAACAGATGGGCGAGATCACTCGCGGCGAACGGGCTCCGTC
TCGCGAGATCCACATCGATGCCGTGCGGGTGAAAGAGGTCCGGGCCGCCACTGGGCTGTCACAGGCGAAATTCGCTCAGG
TGATCGACGTGCAGCTCGGCACCTTGCGTAATTGGGAGCAGGGGCGGCGGAACCCTACGGGGCCTGCCCGAGCGCTGCTG
CGTGCGATCAAGAAGGATCCCAAGAGCGTGCTGGAAGCTCTGTCAGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1L1KDK2


Antitoxin

Source ID Structure
AlphaFold DB V0VAH2

References