Detailed information of TA system TA214599

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3571614..3572028
• Replicon: chromosome
• Accession: NZ_CP082338
• Organism: Salmonella enterica subsp. enterica strain IBG7b4

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V5ZAW1
• Locus tag: K7H10_RS17500
• Protein ID: WP_001749073.1
• Coordinates: 3571771..3572028 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3571614..3571946 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7H10_RS17470	3567216..3567953	-	738	WP_052934507.1	pili assembly chaperone SafB	-
K7H10_RS17475	3568030..3568527	-	498	WP_000789570.1	hypothetical protein	-
K7H10_RS17480	3568660..3569154	-	495	WP_000789624.1	hypothetical protein	-
K7H10_RS17485	3569919..3570620	-	702	Protein_3431	integrase core domain-containing protein	-
K7H10_RS17490	3570673..3570921	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
K7H10_RS17495	3571053..3571331	-	279	WP_077906242.1	hypothetical protein	-
-	3571614..3571946	-	333	-	-	Antitoxin
K7H10_RS17500	3571771..3572028	+	258	WP_001749073.1	SymE family type I addiction module toxin	Toxin
K7H10_RS17505	3572119..3572496	-	378	WP_000739708.1	Imm8 family immunity protein	-
K7H10_RS17510	3573229..3573594	-	366	WP_001231281.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3560148..3595043	34895
	-	flank	IS/Tn	-	-	3569919..3570197	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9561.85 Da
• Isoelectric Point: 5.0770

>T214599 WP_001749073.1 NZ_CP082338:3571771-3572028 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T214599 NZ_CP110148:c4595266-4594733 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT214599 NZ_CP082338:c3571946-3571614 [Salmonella enterica subsp. enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V5ZAW1

Antitoxin