Detailed information of TA system TA212626

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2826022..2826231
• Replicon: chromosome
• Accession: NZ_CP081023
• Organism: Clostridioides difficile strain CD060

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: K2216_RS13205
• Protein ID: WP_003431040.1
• Coordinates: 2826073..2826231 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2826022..2826156 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2216_RS13175 (2821225)	2821225..2821425	+	201	WP_003431034.1	cold-shock protein	-
K2216_RS13180 (2821871)	2821871..2823193	+	1323	WP_021427477.1	ATP-binding protein	-
K2216_RS13185 (2823236)	2823236..2823817	+	582	WP_003431036.1	accessory gene regulator B family protein	-
K2216_RS13190 (2823835)	2823835..2823996	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
K2216_RS13195 (2824018)	2824018..2824815	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
K2216_RS13200 (2824812)	2824812..2825072	-	261	WP_003431039.1	phage holin family protein	-
- (2826022)	2826022..2826156	+	135	NuclAT_1	-	Antitoxin
- (2826022)	2826022..2826156	+	135	NuclAT_1	-	Antitoxin
- (2826022)	2826022..2826156	+	135	NuclAT_2	-	Antitoxin
K2216_RS13205 (2826073)	2826073..2826231	-	159	WP_003431040.1	hypothetical protein	Toxin
K2216_RS13210 (2826589)	2826589..2827959	-	1371	WP_003431041.1	cell wall-binding protein Cwp29	-
K2216_RS13215 (2828394)	2828394..2828780	+	387	WP_231299769.1	hypothetical protein	-
K2216_RS13220 (2829158)	2829158..2829283	+	126	WP_003431043.1	hypothetical protein	-
K2216_RS13225 (2829646)	2829646..2829726	-	81	Protein_2530	VOC family protein	-
K2216_RS13230 (2829766)	2829766..2830434	-	669	WP_003431044.1	VanZ family protein	-
K2216_RS13235 (2830533)	2830533..2830916	-	384	WP_071599195.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T212626 WP_003431040.1 NZ_CP081023:c2826231-2826073 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T212626 NZ_CP107301:c4371-4057 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT212626 NZ_CP081023:2826022-2826156 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin