Detailed information of TA system TA212609

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1348494..1348699
• Replicon: chromosome
• Accession: NZ_CP081021
• Organism: Clostridioides difficile strain G89

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: K2215_RS06330
• Protein ID: WP_009896140.1
• Coordinates: 1348494..1348646 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1348626..1348699 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2215_RS06310 (1343963)	1343963..1344247	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
K2215_RS06315 (1344270)	1344270..1345787	-	1518	WP_021362467.1	recombinase family protein	-
K2215_RS06320 (1345912)	1345912..1346733	-	822	WP_114086324.1	tetratricopeptide repeat protein	-
K2215_RS06325 (1346924)	1346924..1348351	+	1428	WP_114086323.1	cell wall-binding protein Cwp26	-
K2215_RS06330 (1348494)	1348494..1348646	+	153	WP_009896140.1	hypothetical protein	Toxin
- (1348626)	1348626..1348699	-	74	NuclAT_3	-	Antitoxin
- (1348626)	1348626..1348699	-	74	NuclAT_3	-	Antitoxin
- (1348626)	1348626..1348699	-	74	NuclAT_4	-	Antitoxin
K2215_RS06335 (1349680)	1349680..1349904	-	225	WP_003433396.1	helix-turn-helix transcriptional regulator	-
K2215_RS06340 (1350594)	1350594..1350749	+	156	WP_003433394.1	hypothetical protein	-
K2215_RS06345 (1351028)	1351028..1351246	+	219	WP_009889000.1	hypothetical protein	-
K2215_RS06350 (1351555)	1351555..1351680	+	126	WP_003433391.1	hypothetical protein	-
K2215_RS06355 (1352466)	1352466..1352849	-	384	WP_003433385.1	hypothetical protein	-
K2215_RS06360 (1352976)	1352976..1353320	+	345	WP_003433383.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T212609 WP_009896140.1 NZ_CP081021:1348494-1348646 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T212609 NZ_CP107296:1088-1354 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin

Nucleotide

• Length: 74 bp

>AT212609 NZ_CP081021:c1348699-1348626 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin