Detailed information of TA system TA212597

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2842476..2842685
• Replicon: chromosome
• Accession: NZ_CP081017
• Organism: Clostridioides difficile strain SH

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: K2217_RS13265
• Protein ID: WP_003431040.1
• Coordinates: 2842527..2842685 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2842476..2842610 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2217_RS13235 (K2217_13245)	2837810..2838010	+	201	WP_003431034.1	cold-shock protein	-
K2217_RS13240 (K2217_13250)	2838456..2839778	+	1323	WP_021427477.1	ATP-binding protein	-
K2217_RS13245 (K2217_13255)	2839821..2840402	+	582	WP_003431036.1	accessory gene regulator B family protein	-
K2217_RS13250 (K2217_13260)	2840420..2840581	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
K2217_RS13255 (K2217_13265)	2840603..2841400	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
K2217_RS13260 (K2217_13270)	2841397..2841657	-	261	WP_003431039.1	phage holin family protein	-
-	2842476..2842610	+	135	-	-	Antitoxin
K2217_RS13265 (K2217_13275)	2842527..2842685	-	159	WP_003431040.1	hypothetical protein	Toxin
K2217_RS13270 (K2217_13280)	2843043..2844413	-	1371	WP_003431041.1	cell wall-binding protein Cwp29	-
K2217_RS13275 (K2217_13290)	2844848..2845234	+	387	WP_231299769.1	hypothetical protein	-
K2217_RS13280 (K2217_13295)	2845612..2845737	+	126	WP_003431043.1	hypothetical protein	-
K2217_RS13285 (K2217_13300)	2846100..2846180	-	81	Protein_2542	VOC family protein	-
K2217_RS13290 (K2217_13305)	2846220..2846888	-	669	WP_003431044.1	VanZ family protein	-
K2217_RS13295 (K2217_13310)	2846987..2847370	-	384	WP_071599195.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2836645..2845234	8589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T212597 WP_003431040.1 NZ_CP081017:c2842685-2842527 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T212597 NZ_CP107291:c2786186-2784864 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 135 bp

>AT212597 NZ_CP081017:2842476-2842610 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin