Detailed information of TA system TA212593

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1788776..1788990
• Replicon: chromosome
• Accession: NZ_CP081017
• Organism: Clostridioides difficile strain SH

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: K2217_RS08425
• Protein ID: WP_003429855.1
• Coordinates: 1788776..1788937 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1788857..1788990 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2217_RS08380 (K2217_08395)	1784116..1784349	+	234	WP_003433536.1	hypothetical protein	-
K2217_RS08385 (K2217_08400)	1784359..1784760	+	402	WP_009888836.1	hypothetical protein	-
K2217_RS08390 (K2217_08405)	1784754..1785101	+	348	WP_003433540.1	hypothetical protein	-
K2217_RS08395 (K2217_08410)	1785101..1785526	+	426	WP_003433542.1	HK97 gp10 family phage protein	-
K2217_RS08400 (K2217_08415)	1785519..1785956	+	438	WP_003433544.1	hypothetical protein	-
K2217_RS08405 (K2217_08420)	1785949..1786125	+	177	WP_003433548.1	hypothetical protein	-
K2217_RS08410 (K2217_08425)	1786126..1787436	+	1311	WP_003433550.1	phage tail sheath family protein	-
K2217_RS08415 (K2217_08430)	1787453..1787923	+	471	WP_003429851.1	phage tail tube protein	-
K2217_RS08420 (K2217_08435)	1787995..1788435	+	441	WP_003429853.1	phage portal protein	-
K2217_RS08425 (K2217_08440)	1788776..1788937	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1788857..1788990	-	134	-	-	Antitoxin
K2217_RS08430 (K2217_08445)	1790085..1790837	+	753	WP_021387708.1	SHOCT domain-containing protein	-
K2217_RS08435 (K2217_08450)	1791141..1791314	+	174	WP_003433557.1	hypothetical protein	-
K2217_RS08440 (K2217_08455)	1791438..1792265	+	828	WP_003433559.1	hypothetical protein	-
K2217_RS08445 (K2217_08460)	1792314..1792490	+	177	WP_003433561.1	hypothetical protein	-
K2217_RS08450 (K2217_08465)	1792921..1793481	+	561	WP_021387709.1	ribosomal protein L7/L12	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1756558..1826695	70137

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T212593 WP_003429855.1 NZ_CP081017:1788776-1788937 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T212593 NZ_CP107291:355416-355763 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 134 bp

>AT212593 NZ_CP081017:c1788990-1788857 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin