Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1977922..1978104 Replicon chromosome
Accession NZ_CP080556
Organism Staphylococcus aureus strain HL17078

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag JMO10_RS09720 Protein ID WP_001801861.1
Coordinates 1977922..1978017 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1978045..1978104 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO10_RS09680 1973582..1974208 + 627 Protein_1914 hypothetical protein -
JMO10_RS09685 1974249..1974593 + 345 WP_000627551.1 DUF3969 family protein -
JMO10_RS09690 1974691..1975242 + 552 WP_000414205.1 hypothetical protein -
JMO10_RS09695 1975460..1976101 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
JMO10_RS09700 1976215..1976400 - 186 WP_000809857.1 hypothetical protein -
JMO10_RS09705 1976402..1976578 - 177 WP_000375476.1 hypothetical protein -
JMO10_RS09710 1976589..1976972 - 384 WP_000070811.1 hypothetical protein -
JMO10_RS09715 1977576..1977719 - 144 WP_001549059.1 transposase -
JMO10_RS09720 1977922..1978017 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1978045..1978104 - 60 - - Antitoxin
JMO10_RS09725 1978140..1978241 + 102 WP_001791893.1 hypothetical protein -
JMO10_RS09730 1978219..1978395 - 177 Protein_1924 transposase -
JMO10_RS09735 1978589..1978966 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1971022..2011194 40172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T212104 WP_001801861.1 NZ_CP080556:1977922-1978017 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T212104 NZ_CP106965:c154328-153843 [Klebsiella variicola]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAATCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 60 bp

>AT212104 NZ_CP080556:c1978104-1978045 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References