Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1990138..1990318 Replicon chromosome
Accession NZ_CP080548
Organism Staphylococcus aureus strain HL18888

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag JMO15_RS09715 Protein ID WP_001801861.1
Coordinates 1990138..1990233 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1990261..1990318 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMO15_RS09685 1985301..1985951 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
JMO15_RS09690 1986032..1987027 + 996 WP_000070642.1 DUF4352 domain-containing protein -
JMO15_RS09695 1987102..1987728 + 627 WP_000669024.1 hypothetical protein -
JMO15_RS09700 1987769..1988110 + 342 WP_000627540.1 DUF3969 family protein -
JMO15_RS09705 1988211..1988783 + 573 WP_000414216.1 hypothetical protein -
JMO15_RS09710 1988981..1989993 - 1013 Protein_1923 IS3 family transposase -
JMO15_RS09715 1990138..1990233 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1990261..1990318 - 58 - - Antitoxin
JMO15_RS09720 1990356..1990457 + 102 WP_001792025.1 hypothetical protein -
JMO15_RS09725 1990435..1990596 - 162 Protein_1926 transposase -
JMO15_RS09730 1990581..1990991 - 411 WP_001808705.1 IS21 family transposase -
JMO15_RS09735 1991539..1992174 - 636 Protein_1928 restriction endonuclease subunit S -
JMO15_RS09740 1992167..1993723 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
JMO15_RS09745 1993887..1994021 - 135 WP_001791797.1 hypothetical protein -
JMO15_RS09750 1994084..1994803 - 720 WP_220369814.1 serine protease SplF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1984543..2016562 32019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T212030 WP_001801861.1 NZ_CP080548:1990138-1990233 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T212030 NZ_CP106913:c104231-103761 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 58 bp

>AT212030 NZ_CP080548:c1990318-1990261 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References