211413

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1970213..1970393 Replicon chromosome
Accession NZ_CP080249
Organism Staphylococcus aureus strain NV_1

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag KZW86_RS09695 Protein ID WP_001801861.1
Coordinates 1970213..1970308 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1970336..1970393 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW86_RS09665 1965376..1966026 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
KZW86_RS09670 1966107..1967102 + 996 WP_153906686.1 DUF4352 domain-containing protein -
KZW86_RS09675 1967177..1967803 + 627 WP_000669024.1 hypothetical protein -
KZW86_RS09680 1967844..1968185 + 342 WP_000627540.1 DUF3969 family protein -
KZW86_RS09685 1968286..1968858 + 573 WP_000414216.1 hypothetical protein -
KZW86_RS09690 1969056..1970068 - 1013 Protein_1908 IS3 family transposase -
KZW86_RS09695 1970213..1970308 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1970336..1970393 - 58 - - Antitoxin
KZW86_RS09700 1970431..1970532 + 102 WP_001792025.1 hypothetical protein -
KZW86_RS09705 1970510..1970671 - 162 Protein_1911 transposase -
KZW86_RS09710 1970656..1971066 - 411 WP_001808705.1 IS21 family transposase -
KZW86_RS09715 1971608..1972837 - 1230 WP_000072627.1 restriction endonuclease subunit S -
KZW86_RS09720 1972830..1974386 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
KZW86_RS09725 1974550..1974684 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1965412..2003838 38426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T211413 WP_001801861.1 NZ_CP080249:1970213-1970308 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T211413 NZ_CP104857:10474-10815 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGGAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACAATGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATACCCACTCGTTATACATTACCTGATGAAATGGAGACTCATGGTCAAGTCGTTATTTCCCAA
TTAAAATCTTTAGATTTTACAGAAAGAAAGTTAAGCCAAATCGAGCATTTACCATTAAAGGATATGGCTAAAATAAATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 58 bp

>AT211413 NZ_CP080249:c1970393-1970336 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References