Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 930792..932029 | Replicon | chromosome |
| Accession | NZ_CP079923 | ||
| Organism | Streptococcus pneumoniae strain Rx1 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | R4H7C0 |
| Locus tag | KZH43_RS04665 | Protein ID | WP_000405357.1 |
| Coordinates | 931268..932029 (+) | Length | 254 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCC4 |
| Locus tag | KZH43_RS04660 | Protein ID | WP_000579612.1 |
| Coordinates | 930792..931268 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZH43_RS04635 (KZH43_04635) | 925865..926719 | + | 855 | WP_000900020.1 | ADP-ribosylglycohydrolase family protein | - |
| KZH43_RS04640 (KZH43_04640) | 926831..927715 | + | 885 | WP_000710119.1 | diacylglycerol kinase family lipid kinase | - |
| KZH43_RS04645 (KZH43_04645) | 927878..929617 | + | 1740 | WP_000423451.1 | glycoside hydrolase family 13 protein | - |
| KZH43_RS10525 | 929892..930347 | + | 456 | Protein_934 | hypothetical protein | - |
| KZH43_RS04660 (KZH43_04660) | 930792..931268 | + | 477 | WP_000579612.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| KZH43_RS04665 (KZH43_04665) | 931268..932029 | + | 762 | WP_000405357.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| KZH43_RS04670 (KZH43_04670) | 932057..932833 | + | 777 | WP_258404908.1 | hypothetical protein | - |
| KZH43_RS10530 | 932836..933213 | + | 378 | WP_000530001.1 | hypothetical protein | - |
| KZH43_RS04675 (KZH43_04675) | 934045..934404 | + | 360 | WP_000529543.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| KZH43_RS04680 (KZH43_04680) | 934414..934743 | + | 330 | WP_000263037.1 | plasmid mobilization relaxosome protein MobC | - |
| KZH43_RS04685 (KZH43_04685) | 934766..936651 | + | 1886 | Protein_941 | SAG1250 family conjugative relaxase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 916149..948908 | 32759 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 254 a.a. Molecular weight: 29044.10 Da Isoelectric Point: 7.1307
>T210369 WP_000405357.1 NZ_CP079923:931268-932029 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
Download Length: 762 bp
>T210369 NZ_CP104509:c335223-334849 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT210369 WP_000579612.1 NZ_CP079923:930792-931268 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT210369 NZ_CP104509:c335681-335313 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|