Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 936254..937491 | Replicon | chromosome |
| Accession | NZ_CP079922 | ||
| Organism | Streptococcus pneumoniae strain R36A | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | R4H7C0 |
| Locus tag | KZB15_RS04665 | Protein ID | WP_000405357.1 |
| Coordinates | 936730..937491 (+) | Length | 254 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | B6ZCC4 |
| Locus tag | KZB15_RS04660 | Protein ID | WP_000579612.1 |
| Coordinates | 936254..936730 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZB15_RS04635 (KZB15_04645) | 931327..932181 | + | 855 | WP_000900020.1 | ADP-ribosylglycohydrolase family protein | - |
| KZB15_RS04640 (KZB15_04650) | 932293..933177 | + | 885 | WP_000710119.1 | diacylglycerol kinase family lipid kinase | - |
| KZB15_RS04645 (KZB15_04655) | 933340..935079 | + | 1740 | WP_000423451.1 | glycoside hydrolase family 13 protein | - |
| KZB15_RS10545 | 935354..935809 | + | 456 | Protein_935 | hypothetical protein | - |
| KZB15_RS04660 (KZB15_04670) | 936254..936730 | + | 477 | WP_000579612.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| KZB15_RS04665 (KZB15_04675) | 936730..937491 | + | 762 | WP_000405357.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| KZB15_RS04670 (KZB15_04680) | 937519..938295 | + | 777 | WP_001821017.1 | hypothetical protein | - |
| KZB15_RS10550 | 938298..938675 | + | 378 | WP_000530001.1 | hypothetical protein | - |
| KZB15_RS04675 (KZB15_04685) | 939507..939866 | + | 360 | WP_000529543.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| KZB15_RS04680 (KZB15_04690) | 939876..940205 | + | 330 | WP_000263037.1 | plasmid mobilization relaxosome protein MobC | - |
| KZB15_RS04685 (KZB15_04695) | 940228..942113 | + | 1886 | Protein_942 | SAG1250 family conjugative relaxase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 921610..954371 | 32761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 254 a.a. Molecular weight: 29044.10 Da Isoelectric Point: 7.1307
>T210365 WP_000405357.1 NZ_CP079922:936730-937491 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK
Download Length: 762 bp
>T210365 NZ_CP104504:c319079-318801 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 159 a.a. Molecular weight: 18245.68 Da Isoelectric Point: 4.4188
>AT210365 WP_000579612.1 NZ_CP079922:936254-936730 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT210365 NZ_CP104504:c319348-319079 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|