Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 936254..937491 Replicon chromosome
Accession NZ_CP079922
Organism Streptococcus pneumoniae strain R36A

Toxin (Protein)


Gene name pezT Uniprot ID R4H7C0
Locus tag KZB15_RS04665 Protein ID WP_000405357.1
Coordinates 936730..937491 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag KZB15_RS04660 Protein ID WP_000579612.1
Coordinates 936254..936730 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZB15_RS04635 (KZB15_04645) 931327..932181 + 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -
KZB15_RS04640 (KZB15_04650) 932293..933177 + 885 WP_000710119.1 diacylglycerol kinase family lipid kinase -
KZB15_RS04645 (KZB15_04655) 933340..935079 + 1740 WP_000423451.1 glycoside hydrolase family 13 protein -
KZB15_RS10545 935354..935809 + 456 Protein_935 hypothetical protein -
KZB15_RS04660 (KZB15_04670) 936254..936730 + 477 WP_000579612.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
KZB15_RS04665 (KZB15_04675) 936730..937491 + 762 WP_000405357.1 type II toxin-antitoxin system toxin PezT Toxin
KZB15_RS04670 (KZB15_04680) 937519..938295 + 777 WP_001821017.1 hypothetical protein -
KZB15_RS10550 938298..938675 + 378 WP_000530001.1 hypothetical protein -
KZB15_RS04675 (KZB15_04685) 939507..939866 + 360 WP_000529543.1 SAG1252 family conjugative relaxosome accessory protein -
KZB15_RS04680 (KZB15_04690) 939876..940205 + 330 WP_000263037.1 plasmid mobilization relaxosome protein MobC -
KZB15_RS04685 (KZB15_04695) 940228..942113 + 1886 Protein_942 SAG1250 family conjugative relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 921610..954371 32761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29044.10 Da        Isoelectric Point: 7.1307

>T210365 WP_000405357.1 NZ_CP079922:936730-937491 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T210365 NZ_CP104504:c319079-318801 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT210365 WP_000579612.1 NZ_CP079922:936254-936730 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT210365 NZ_CP104504:c319348-319079 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R4H7C0

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References