Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 1416046..1416745 | Replicon | chromosome |
| Accession | NC_005126 | ||
| Organism | Photorhabdus luminescens subsp. laumondii TTO1 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | Q7N7C8 |
| Locus tag | PLU_RS06045 | Protein ID | WP_011145550.1 |
| Coordinates | 1416365..1416745 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | Q7N7C9 |
| Locus tag | PLU_RS06040 | Protein ID | WP_011145549.1 |
| Coordinates | 1416046..1416384 (-) | Length | 113 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PLU_RS06030 (plu1221) | 1414056..1414406 | + | 351 | WP_041379972.1 | aminotransferase class III-fold pyridoxal phosphate-dependent enzyme | - |
| PLU_RS06035 (plu1222) | 1414713..1415717 | + | 1005 | WP_011145548.1 | IS110-like element ISPlu13 family transposase | - |
| PLU_RS06040 (plu1223) | 1416046..1416384 | - | 339 | WP_011145549.1 | helix-turn-helix domain-containing protein | Antitoxin |
| PLU_RS06045 (plu1224) | 1416365..1416745 | - | 381 | WP_011145550.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| PLU_RS06050 (plu1225) | 1417030..1418034 | + | 1005 | WP_011145548.1 | IS110-like element ISPlu13 family transposase | - |
| PLU_RS06055 (plu1226) | 1418302..1419639 | - | 1338 | WP_011145551.1 | MSMEG_0569 family flavin-dependent oxidoreductase | - |
| PLU_RS06060 (plu1227) | 1419652..1419942 | - | 291 | WP_011145552.1 | MSMEG_0570 family nitrogen starvation response protein | - |
| PLU_RS06065 (plu1228) | 1419930..1420985 | - | 1056 | WP_041379973.1 | sll0787 family AIR synthase-like protein | - |
| PLU_RS06070 (plu1229) | 1420982..1421545 | - | 564 | WP_011145554.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | IScluster/Tn | - | - | 1414713..1418034 | 3321 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14281.46 Da Isoelectric Point: 8.5211
>T20997 WP_011145550.1 NC_005126:c1416745-1416365 [Photorhabdus laumondii subsp. laumondii TTO1]
MEQQSEKLLVWIGSSKKDLLNLPKDVQRFFGFALDFAQRGEKHDAVKVMKGFGGAGVLEVLEDDIGGTYRAVYTVKFDEA
VFVLHAFQKKSKHGIATPKEDMDIIRNRLKVAAVMAQEMKNERENH
MEQQSEKLLVWIGSSKKDLLNLPKDVQRFFGFALDFAQRGEKHDAVKVMKGFGGAGVLEVLEDDIGGTYRAVYTVKFDEA
VFVLHAFQKKSKHGIATPKEDMDIIRNRLKVAAVMAQEMKNERENH
Download Length: 381 bp
>T20997 NC_005126:c1416745-1416365 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGGAGCAACAAAGTGAAAAGCTGCTAGTGTGGATAGGCAGCAGCAAGAAGGACTTGCTGAACTTGCCGAAGGACGTGCA
GCGCTTCTTTGGCTTTGCCCTAGACTTCGCGCAGCGTGGCGAAAAGCATGATGCTGTGAAGGTGATGAAAGGGTTTGGTG
GTGCCGGCGTTCTGGAAGTGTTGGAGGACGACATAGGTGGTACCTACCGAGCGGTGTATACGGTGAAATTTGACGAAGCG
GTCTTTGTGCTACATGCCTTTCAGAAGAAGAGTAAGCACGGCATAGCGACGCCGAAAGAAGATATGGACATCATCCGTAA
TCGACTGAAAGTGGCCGCTGTGATGGCCCAGGAGATGAAAAATGAAAGAGAAAACCATTAA
ATGGAGCAACAAAGTGAAAAGCTGCTAGTGTGGATAGGCAGCAGCAAGAAGGACTTGCTGAACTTGCCGAAGGACGTGCA
GCGCTTCTTTGGCTTTGCCCTAGACTTCGCGCAGCGTGGCGAAAAGCATGATGCTGTGAAGGTGATGAAAGGGTTTGGTG
GTGCCGGCGTTCTGGAAGTGTTGGAGGACGACATAGGTGGTACCTACCGAGCGGTGTATACGGTGAAATTTGACGAAGCG
GTCTTTGTGCTACATGCCTTTCAGAAGAAGAGTAAGCACGGCATAGCGACGCCGAAAGAAGATATGGACATCATCCGTAA
TCGACTGAAAGTGGCCGCTGTGATGGCCCAGGAGATGAAAAATGAAAGAGAAAACCATTAA
Antitoxin
Download Length: 113 a.a. Molecular weight: 12213.14 Da Isoelectric Point: 9.8793
>AT20997 WP_011145549.1 NC_005126:c1416384-1416046 [Photorhabdus laumondii subsp. laumondii TTO1]
MKEKTINGVAVEISSGNVFADLGFRDAEKHKIKSGLAFEIIKSIKRLGLTQTTAGERIGISQAKVSHLFRGDFSNLSERK
MMECLNRLGCDIEITVKPTTAQTGHLILAHSG
MKEKTINGVAVEISSGNVFADLGFRDAEKHKIKSGLAFEIIKSIKRLGLTQTTAGERIGISQAKVSHLFRGDFSNLSERK
MMECLNRLGCDIEITVKPTTAQTGHLILAHSG
Download Length: 339 bp
>AT20997 NC_005126:c1416384-1416046 [Photorhabdus laumondii subsp. laumondii TTO1]
ATGAAAGAGAAAACCATTAATGGCGTAGCGGTTGAAATCAGCTCCGGCAACGTGTTTGCCGATCTGGGTTTCCGTGATGC
CGAAAAGCACAAAATTAAATCCGGCTTGGCCTTTGAGATCATCAAATCTATCAAGCGTCTGGGGCTGACACAAACTACTG
CTGGCGAACGTATTGGGATCAGCCAGGCAAAAGTATCCCACCTGTTCCGGGGCGATTTTTCCAACCTGTCAGAACGTAAG
ATGATGGAGTGTCTGAATCGGCTGGGGTGTGACATCGAGATCACTGTCAAGCCGACTACTGCCCAAACCGGGCATTTAAT
TTTGGCACATAGCGGGTAA
ATGAAAGAGAAAACCATTAATGGCGTAGCGGTTGAAATCAGCTCCGGCAACGTGTTTGCCGATCTGGGTTTCCGTGATGC
CGAAAAGCACAAAATTAAATCCGGCTTGGCCTTTGAGATCATCAAATCTATCAAGCGTCTGGGGCTGACACAAACTACTG
CTGGCGAACGTATTGGGATCAGCCAGGCAAAAGTATCCCACCTGTTCCGGGGCGATTTTTCCAACCTGTCAGAACGTAAG
ATGATGGAGTGTCTGAATCGGCTGGGGTGTGACATCGAGATCACTGTCAAGCCGACTACTGCCCAAACCGGGCATTTAAT
TTTGGCACATAGCGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JUM5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JSP2 |