62838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1416046..1416745 Replicon chromosome
Accession NZ_CP015281
Organism Photorhabdus laumondii subsp. laumondii strain DSPV002N

Toxin (Protein)


Gene name tad Uniprot ID Q7N7C8
Locus tag A4R40_RS06250 Protein ID WP_011145550.1
Coordinates 1416365..1416745 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID Q7N7C9
Locus tag A4R40_RS06245 Protein ID WP_011145549.1
Coordinates 1416046..1416384 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R40_RS06235 1414056..1414406 + 351 WP_041379972.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
A4R40_RS06240 1414713..1415717 + 1005 WP_011145548.1 IS110-like element ISPlu13 family transposase -
A4R40_RS06245 1416046..1416384 - 339 WP_011145549.1 helix-turn-helix domain-containing protein Antitoxin
A4R40_RS06250 1416365..1416745 - 381 WP_011145550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R40_RS06255 1417030..1418034 + 1005 WP_011145548.1 IS110-like element ISPlu13 family transposase -
A4R40_RS06260 1418302..1419639 - 1338 WP_011145551.1 MSMEG_0569 family flavin-dependent oxidoreductase -
A4R40_RS06265 1419652..1419942 - 291 WP_011145552.1 MSMEG_0570 family nitrogen starvation response protein -
A4R40_RS06270 1419930..1420985 - 1056 WP_041379973.1 sll0787 family AIR synthase-like protein -
A4R40_RS06275 1420982..1421545 - 564 WP_011145554.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 1414713..1418034 3321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14281.46 Da        Isoelectric Point: 8.5211

>T62838 WP_011145550.1 NZ_CP015281:c1416745-1416365 [Photorhabdus laumondii subsp. laumondii]
MEQQSEKLLVWIGSSKKDLLNLPKDVQRFFGFALDFAQRGEKHDAVKVMKGFGGAGVLEVLEDDIGGTYRAVYTVKFDEA
VFVLHAFQKKSKHGIATPKEDMDIIRNRLKVAAVMAQEMKNERENH

Download         Length: 381 bp

>T62838 NZ_CP015281:c1416745-1416365 [Photorhabdus laumondii subsp. laumondii]
ATGGAGCAACAAAGTGAAAAGCTGCTAGTGTGGATAGGCAGCAGCAAGAAGGACTTGCTGAACTTGCCGAAGGACGTGCA
GCGCTTCTTTGGCTTTGCCCTAGACTTCGCGCAGCGTGGCGAAAAGCATGATGCTGTGAAGGTGATGAAAGGGTTTGGTG
GTGCCGGCGTTCTGGAAGTGTTGGAGGACGACATAGGTGGTACCTACCGAGCGGTGTATACGGTGAAATTTGACGAAGCG
GTCTTTGTGCTACATGCCTTTCAGAAGAAGAGTAAGCACGGCATAGCGACGCCGAAAGAAGATATGGACATCATCCGTAA
TCGACTGAAAGTGGCCGCTGTGATGGCCCAGGAGATGAAAAATGAAAGAGAAAACCATTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12213.14 Da        Isoelectric Point: 9.8793

>AT62838 WP_011145549.1 NZ_CP015281:c1416384-1416046 [Photorhabdus laumondii subsp. laumondii]
MKEKTINGVAVEISSGNVFADLGFRDAEKHKIKSGLAFEIIKSIKRLGLTQTTAGERIGISQAKVSHLFRGDFSNLSERK
MMECLNRLGCDIEITVKPTTAQTGHLILAHSG

Download         Length: 339 bp

>AT62838 NZ_CP015281:c1416384-1416046 [Photorhabdus laumondii subsp. laumondii]
ATGAAAGAGAAAACCATTAATGGCGTAGCGGTTGAAATCAGCTCCGGCAACGTGTTTGCCGATCTGGGTTTCCGTGATGC
CGAAAAGCACAAAATTAAATCCGGCTTGGCCTTTGAGATCATCAAATCTATCAAGCGTCTGGGGCTGACACAAACTACTG
CTGGCGAACGTATTGGGATCAGCCAGGCAAAAGTATCCCACCTGTTCCGGGGCGATTTTTCCAACCTGTCAGAACGTAAG
ATGATGGAGTGTCTGAATCGGCTGGGGTGTGACATCGAGATCACTGTCAAGCCGACTACTGCCCAAACCGGGCATTTAAT
TTTGGCACATAGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JUM5

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JSP2

References