89165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1326257..1326956 Replicon chromosome
Accession NZ_CP024900
Organism Photorhabdus laumondii subsp. laumondii strain DJC

Toxin (Protein)


Gene name tad Uniprot ID Q7N7C8
Locus tag PluDJC_RS05860 Protein ID WP_011145550.1
Coordinates 1326576..1326956 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID Q7N7C9
Locus tag PluDJC_RS05855 Protein ID WP_011145549.1
Coordinates 1326257..1326595 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PluDJC_RS05845 1324267..1324617 + 351 WP_041379972.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
PluDJC_RS05850 1324924..1325928 + 1005 WP_011145548.1 IS110-like element ISPlu13 family transposase -
PluDJC_RS05855 1326257..1326595 - 339 WP_011145549.1 helix-turn-helix domain-containing protein Antitoxin
PluDJC_RS05860 1326576..1326956 - 381 WP_011145550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PluDJC_RS05865 1327241..1328245 + 1005 WP_011145548.1 IS110-like element ISPlu13 family transposase -
PluDJC_RS05870 1328513..1329850 - 1338 WP_011145551.1 MSMEG_0569 family flavin-dependent oxidoreductase -
PluDJC_RS05875 1329863..1330153 - 291 WP_011145552.1 MSMEG_0570 family nitrogen starvation response protein -
PluDJC_RS05880 1330141..1331196 - 1056 WP_041379973.1 sll0787 family AIR synthase-like protein -
PluDJC_RS05885 1331193..1331756 - 564 WP_011145554.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 1324924..1328245 3321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14281.46 Da        Isoelectric Point: 8.5211

>T89165 WP_011145550.1 NZ_CP024900:c1326956-1326576 [Photorhabdus laumondii subsp. laumondii]
MEQQSEKLLVWIGSSKKDLLNLPKDVQRFFGFALDFAQRGEKHDAVKVMKGFGGAGVLEVLEDDIGGTYRAVYTVKFDEA
VFVLHAFQKKSKHGIATPKEDMDIIRNRLKVAAVMAQEMKNERENH

Download         Length: 381 bp

>T89165 NZ_CP024900:c1326956-1326576 [Photorhabdus laumondii subsp. laumondii]
ATGGAGCAACAAAGTGAAAAGCTGCTAGTGTGGATAGGCAGCAGCAAGAAGGACTTGCTGAACTTGCCGAAGGACGTGCA
GCGCTTCTTTGGCTTTGCCCTAGACTTCGCGCAGCGTGGCGAAAAGCATGATGCTGTGAAGGTGATGAAAGGGTTTGGTG
GTGCCGGCGTTCTGGAAGTGTTGGAGGACGACATAGGTGGTACCTACCGAGCGGTGTATACGGTGAAATTTGACGAAGCG
GTCTTTGTGCTACATGCCTTTCAGAAGAAGAGTAAGCACGGCATAGCGACGCCGAAAGAAGATATGGACATCATCCGTAA
TCGACTGAAAGTGGCCGCTGTGATGGCCCAGGAGATGAAAAATGAAAGAGAAAACCATTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12213.14 Da        Isoelectric Point: 9.8793

>AT89165 WP_011145549.1 NZ_CP024900:c1326595-1326257 [Photorhabdus laumondii subsp. laumondii]
MKEKTINGVAVEISSGNVFADLGFRDAEKHKIKSGLAFEIIKSIKRLGLTQTTAGERIGISQAKVSHLFRGDFSNLSERK
MMECLNRLGCDIEITVKPTTAQTGHLILAHSG

Download         Length: 339 bp

>AT89165 NZ_CP024900:c1326595-1326257 [Photorhabdus laumondii subsp. laumondii]
ATGAAAGAGAAAACCATTAATGGCGTAGCGGTTGAAATCAGCTCCGGCAACGTGTTTGCCGATCTGGGTTTCCGTGATGC
CGAAAAGCACAAAATTAAATCCGGCTTGGCCTTTGAGATCATCAAATCTATCAAGCGTCTGGGGCTGACACAAACTACTG
CTGGCGAACGTATTGGGATCAGCCAGGCAAAAGTATCCCACCTGTTCCGGGGCGATTTTTCCAACCTGTCAGAACGTAAG
ATGATGGAGTGTCTGAATCGGCTGGGGTGTGACATCGAGATCACTGTCAAGCCGACTACTGCCCAAACCGGGCATTTAAT
TTTGGCACATAGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JUM5

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JSP2

References