Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-orzP/SymE(toxin)
Location 4494514..4494926 Replicon chromosome
Accession NZ_CP077969
Organism Escherichia coli strain JM83

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag KTJ86_RS21700 Protein ID WP_000132601.1
Coordinates 4494514..4494855 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name orzP
Locus tag -
Coordinates 4494850..4494926 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ86_RS21690 (4491927) 4491927..4492973 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
KTJ86_RS21695 (4492973) 4492973..4494352 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
KTJ86_RS21700 (4494514) 4494514..4494855 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4494850) 4494850..4494926 + 77 NuclAT_13 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_13 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_13 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_13 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_14 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_14 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_14 - Antitoxin
- (4494850) 4494850..4494926 + 77 NuclAT_14 - Antitoxin
KTJ86_RS21705 (4495083) 4495083..4496477 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
KTJ86_RS21710 (4496474) 4496474..4498063 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4487429..4496477 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T208778 WP_000132601.1 NZ_CP077969:c4494855-4494514 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T208778 NZ_CP103729:353663-353989 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTATGGCTGACAGAGAATT
CAGCTAA

Antitoxin


Download         Length: 77 bp

>AT208778 NZ_CP077969:4494850-4494926 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References