Detailed information of TA system TA208395

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 50136..50318
• Replicon: chromosome
• Accession: NZ_CP077888
• Organism: Staphylococcus aureus strain 334

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU519_RS00260
• Protein ID: WP_001801861.1
• Coordinates: 50136..50231 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	50259..50318 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU519_RS00220	45796..46422	+	627	WP_000669046.1	hypothetical protein	-
KU519_RS00225	46463..46807	+	345	WP_000627551.1	DUF3969 family protein	-
KU519_RS00230	46905..47456	+	552	WP_000414205.1	hypothetical protein	-
KU519_RS00235	47674..48315	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU519_RS00240	48429..48614	-	186	WP_000809857.1	hypothetical protein	-
KU519_RS00245	48616..48792	-	177	WP_000375476.1	hypothetical protein	-
KU519_RS00250	48803..49186	-	384	WP_000070811.1	hypothetical protein	-
KU519_RS00255	49790..49933	-	144	WP_001549059.1	transposase	-
KU519_RS00260	50136..50231	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	50259..50318	-	60	-	-	Antitoxin
KU519_RS00265	50354..50455	+	102	WP_001791893.1	hypothetical protein	-
KU519_RS00270	50433..50609	-	177	Protein_53	transposase	-
KU519_RS00275	50803..51180	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_009641 Staphylococcus aureus subsp. aureus str. Newman Prophage TA010024 1882747..1922929 0	inside	Prophage	-	lukD / hlgA	43236..83408	40172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208395 WP_001801861.1 NZ_CP077888:50136-50231 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208395 NZ_CP103633:c4011156-4010236 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGTATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACTGATCTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATACAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT208395 NZ_CP077888:c50318-50259 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin