Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 787057..787237 Replicon chromosome
Accession NZ_CP077860
Organism Staphylococcus aureus strain AC4

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag KU521_RS03675 Protein ID WP_001801861.1
Coordinates 787057..787152 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 787180..787237 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU521_RS03645 782219..782869 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
KU521_RS03650 782950..783945 + 996 WP_000070642.1 DUF4352 domain-containing protein -
KU521_RS03655 784021..784647 + 627 WP_000669024.1 hypothetical protein -
KU521_RS03660 784688..785029 + 342 WP_000627540.1 DUF3969 family protein -
KU521_RS03665 785130..785702 + 573 WP_000414216.1 hypothetical protein -
KU521_RS03670 785900..786912 - 1013 Protein_731 IS3 family transposase -
KU521_RS03675 787057..787152 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 787180..787237 - 58 - - Antitoxin
KU521_RS03680 787275..787376 + 102 WP_001792025.1 hypothetical protein -
KU521_RS03685 787354..787515 - 162 Protein_734 transposase -
KU521_RS03690 787500..787910 - 411 WP_001808705.1 IS21 family transposase -
KU521_RS03695 788452..789681 - 1230 WP_000072627.1 restriction endonuclease subunit S -
KU521_RS03700 789674..791230 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
KU521_RS03705 791394..791528 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 781461..814070 32609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T208219 WP_001801861.1 NZ_CP077860:787057-787152 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T208219 NZ_CP103592:c4884269-4883958 [Escherichia coli O25b:H4-ST131]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 58 bp

>AT208219 NZ_CP077860:c787237-787180 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References