208127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 2686800..2686980 Replicon chromosome
Accession NZ_CP077854
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag KU508_RS13185 Protein ID WP_001801861.1
Coordinates 2686800..2686895 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2686923..2686980 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU508_RS13155 2681962..2682612 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
KU508_RS13160 2682693..2683688 + 996 WP_000070642.1 DUF4352 domain-containing protein -
KU508_RS13165 2683764..2684390 + 627 WP_000669024.1 hypothetical protein -
KU508_RS13170 2684431..2684772 + 342 WP_000627540.1 DUF3969 family protein -
KU508_RS13175 2684873..2685445 + 573 WP_000414216.1 hypothetical protein -
KU508_RS13180 2685643..2686655 - 1013 Protein_2594 IS3 family transposase -
KU508_RS13185 2686800..2686895 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 2686923..2686980 - 58 - - Antitoxin
KU508_RS13190 2687018..2687119 + 102 WP_001792025.1 hypothetical protein -
KU508_RS13195 2687097..2687258 - 162 Protein_2597 transposase -
KU508_RS13200 2687243..2687653 - 411 WP_001808705.1 IS21 family transposase -
KU508_RS13205 2688195..2689424 - 1230 WP_000072627.1 restriction endonuclease subunit S -
KU508_RS13210 2689417..2690973 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
KU508_RS13215 2691137..2691271 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 2681204..2713813 32609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T208127 WP_001801861.1 NZ_CP077854:2686800-2686895 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T208127 NZ_CP103577:c300191-299889 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
CTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCTGTGGGAGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 58 bp

>AT208127 NZ_CP077854:c2686980-2686923 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References