Detailed information of TA system TA208097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 68710..68890
• Replicon: chromosome
• Accession: NZ_CP077853
• Organism: Staphylococcus aureus strain N5

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU499_RS00515
• Protein ID: WP_001801861.1
• Coordinates: 68795..68890 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	68710..68767 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU499_RS00485	64419..64553	+	135	WP_001791797.1	hypothetical protein	-
KU499_RS00490	64717..66273	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
KU499_RS00495	66266..67495	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
KU499_RS00500	68037..68447	+	411	WP_001808705.1	IS21 family transposase	-
KU499_RS00505	68432..68593	+	162	Protein_61	transposase	-
KU499_RS00510	68571..68672	-	102	WP_001792025.1	hypothetical protein	-
-	68710..68767	+	58	-	-	Antitoxin
KU499_RS00515	68795..68890	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
KU499_RS00520	69035..70047	+	1013	Protein_64	IS3 family transposase	-
KU499_RS00525	70245..70817	-	573	WP_000414216.1	hypothetical protein	-
KU499_RS00530	70918..71259	-	342	WP_000627540.1	DUF3969 family protein	-
KU499_RS00535	71300..71926	-	627	WP_000669024.1	hypothetical protein	-
KU499_RS00540	72002..72997	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
KU499_RS00545	73078..73728	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002745 Staphylococcus aureus subsp. aureus N315 Prophage TA020384 1850940..1883547 0.007	inside	Prophage	-	selk / hlgA / lukD	32911..74486	41575

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208097 WP_001801861.1 NZ_CP077853:c68890-68795 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208097 NZ_CP103567:c4665772-4665239 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208097 NZ_CP077853:68710-68767 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin