Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15401..15659 Replicon chromosome
Accession NC_004337
Organism Shigella flexneri 2a str. 301

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag SF0015a Protein ID YP_008439227.1
Coordinates 15401..15553 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15602..15659 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SF0012 10642..11355 - 714 NP_705971.1 hypothetical protein -
SF0013 11381..11785 - 405 NP_705972.1 hypothetical protein -
SF0014 12162..14078 + 1917 NP_705973.1 molecular chaperone DnaK -
SF0015 14167..15297 + 1131 NP_705974.2 molecular chaperone DnaJ -
SF0015a 15401..15553 - 153 YP_008439227.1 hypothetical protein Toxin
- 15602..15659 + 58 - - Antitoxin
SF0016 16140..17306 + 1167 NP_705975.1 pH-dependent sodium/proton antiporter -
SF0017 17372..18271 + 900 NP_705976.2 transcriptional activator NhaR -
SF0018 18684..19079 - 396 NP_705977.1 insertion element IS1 protein InsB -
SF0019 19106..19381 - 276 NP_705978.1 insertion element IS1 protein InsA -
SF0020 19770..20033 - 264 NP_705979.5 30S ribosomal protein S20 -
SF0020a 20136..20354 + 219 YP_008439228.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 18684..19187 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T20774 YP_008439227.1 NC_004337:c15553-15401 [Shigella flexneri 2a str. 301]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T20774 NC_004337:c15553-15401 [Shigella flexneri 2a str. 301]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT20774 NC_004337:15602-15659 [Shigella flexneri 2a str. 301]
GTTCAGCATATAGGAGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References