Detailed information of TA system TA207596

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3741303..3741725
• Replicon: chromosome
• Accession: NZ_CP077704
• Organism: Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: DBO17_RS18475
• Protein ID: WP_000994224.1
• Coordinates: 3741450..3741725 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3741303..3741715 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO17_RS18440	3737151..3737669	-	519	WP_001056552.1	fimbrial protein TcfB	-
DBO17_RS18445	3737777..3738487	-	711	WP_001009507.1	fimbrial chaperone TcfA	-
DBO17_RS24195	3739302..3739532	-	231	WP_000564357.1	hypothetical protein	-
DBO17_RS18450	3739524..3740081	+	558	Protein_3643	ATP-binding protein	-
DBO17_RS18455	3740146..3740307	-	162	Protein_3644	transposase	-
DBO17_RS18460	3740360..3740674	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
DBO17_RS18465	3740741..3741019	-	279	WP_012543321.1	hypothetical protein	-
DBO17_RS24200	3741102..3741218	-	117	WP_227457392.1	hypothetical protein	-
-	3741303..3741715	-	413	-	-	Antitoxin
DBO17_RS18475	3741450..3741725	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
DBO17_RS18480	3741778..3742260	-	483	WP_249266879.1	immunity 26/phosphotriesterase HocA family protein	-
DBO17_RS18485	3742779..3743225	-	447	WP_000935097.1	protein SciX	-
DBO17_RS18490	3743219..3744187	-	969	Protein_3651	polymorphic toxin type 47 domain-containing protein	-
DBO17_RS18495	3744614..3744748	+	135	Protein_3652	type I toxin-antitoxin system SymE family toxin	-
DBO17_RS18500	3744817..3745104	-	288	WP_017442165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3730199..3745104	14905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T207596 WP_000994224.1 NZ_CP077704:3741450-3741725 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T207596 NZ_CP103420:798752-799162 [Klebsiella variicola]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 413 bp

>AT207596 NZ_CP077704:c3741715-3741303 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin