Detailed information of TA system TA207515

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3854420..3854852
• Replicon: chromosome
• Accession: NZ_CP077693
• Organism: Salmonella enterica subsp. enterica strain CFSAN058605

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: DAY14_RS19065
• Protein ID: WP_000994224.1
• Coordinates: 3854577..3854852 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3854420..3854842 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAY14_RS19035	3850018..3850755	-	738	WP_023197904.1	pili assembly chaperone SafB	-
DAY14_RS19040	3850832..3851329	-	498	WP_000789570.1	hypothetical protein	-
DAY14_RS19045	3851462..3851956	-	495	WP_023237135.1	Saf-pilin pilus formation protein SafA	-
DAY14_RS19050	3852725..3853426	-	702	Protein_3756	integrase core domain-containing protein	-
DAY14_RS19055	3853479..3853727	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
DAY14_RS19060	3853859..3854137	-	279	WP_077906242.1	hypothetical protein	-
-	3854420..3854842	-	423	-	-	Antitoxin
DAY14_RS19065	3854577..3854852	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
DAY14_RS19070	3854905..3855315	-	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
DAY14_RS19075	3855834..3856280	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gmhA/lpcA	3785420..3863031	77611
	-	flank	IS/Tn	-	-	3852725..3853003	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T207515 WP_000994224.1 NZ_CP077693:3854577-3854852 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T207515 NZ_CP103316:108508-108819 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 423 bp

>AT207515 NZ_CP077693:c3854842-3854420 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin