Detailed information of TA system TA207493

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3848120..3848552
• Replicon: chromosome
• Accession: NZ_CP077691
• Organism: Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: DAX98_RS19030
• Protein ID: WP_000994224.1
• Coordinates: 3848277..3848552 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3848120..3848542 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX98_RS19000	3843718..3844455	-	738	WP_023197904.1	pili assembly chaperone SafB	-
DAX98_RS19005	3844532..3845029	-	498	WP_000789570.1	hypothetical protein	-
DAX98_RS19010	3845162..3845656	-	495	WP_108450242.1	hypothetical protein	-
DAX98_RS19015	3846425..3847126	-	702	Protein_3744	integrase core domain-containing protein	-
DAX98_RS19020	3847179..3847427	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
DAX98_RS19025	3847559..3847837	-	279	WP_077906242.1	hypothetical protein	-
-	3848120..3848542	-	423	-	-	Antitoxin
DAX98_RS19030	3848277..3848552	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
DAX98_RS19035	3848605..3849015	-	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
DAX98_RS19040	3849534..3849980	-	447	WP_000935097.1	protein SciX	-
DAX98_RS25705	3849974..3850123	-	150	WP_254683669.1	polymorphic toxin type 47 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3836650..3850104	13454
	-	flank	IS/Tn	-	-	3846425..3846703	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T207493 WP_000994224.1 NZ_CP077691:3848277-3848552 [Salmonella enterica subsp. enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T207493 NZ_CP103307:797251-797598 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Nucleotide

• Length: 423 bp

>AT207493 NZ_CP077691:c3848542-3848120 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin