Detailed information of TA system TA207458

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1230563..1230977
• Replicon: chromosome
• Accession: NZ_CP077680
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: KTJ81_RS05710
• Protein ID: WP_023203422.1
• Coordinates: 1230563..1230820 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1230645..1230977 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTJ81_RS05695	1228888..1229409	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
KTJ81_RS05700	1229770..1230177	+	408	WP_024146273.1	DUF4329 domain-containing protein	-
KTJ81_RS05705	1230196..1230504	+	309	WP_023203423.1	hypothetical protein	-
KTJ81_RS05710	1230563..1230820	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	1230645..1230977	+	333	-	-	Antitoxin
KTJ81_RS05715	1231893..1232168	+	276	WP_223163371.1	hypothetical protein	-
KTJ81_RS05720	1232261..1232728	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
KTJ81_RS05725	1233046..1233324	+	279	WP_012664366.1	hypothetical protein	-
KTJ81_RS05730	1233469..1233705	-	237	Protein_1107	type I toxin-antitoxin system SymE family toxin	-
KTJ81_RS05735	1233758..1234462	+	705	Protein_1108	integrase core domain-containing protein	-
KTJ81_RS05740	1235223..1235720	+	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1196892..1253691	56799
	-	flank	IS/Tn	-	-	1234181..1234462	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T207458 WP_023203422.1 NZ_CP077680:c1230820-1230563 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T207458 NZ_CP103293:c1604300-1604037 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTTAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAAAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACCGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATAATAGGTAG

Antitoxin

Nucleotide

• Length: 333 bp

>AT207458 NZ_CP077680:1230645-1230977 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin