Detailed information of TA system TA207367

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3681701..3682123
• Replicon: chromosome
• Accession: NZ_CP077662
• Organism: Salmonella enterica strain S146

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V8R754
• Locus tag: KTP10_RS17915
• Protein ID: WP_023232369.1
• Coordinates: 3681848..3682123 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3681701..3682113 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP10_RS17885	3676970..3677467	-	498	WP_048348967.1	Saf-pilin pilus formation protein SafA	-
KTP10_RS17890	3678216..3678920	-	705	Protein_3500	integrase core domain-containing protein	-
KTP10_RS17895	3678973..3679287	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
KTP10_RS17900	3679354..3679632	-	279	WP_012543321.1	hypothetical protein	-
KTP10_RS17905	3679950..3680417	-	468	WP_023232370.1	hypothetical protein	-
KTP10_RS17910	3681290..3681523	-	234	WP_124741005.1	hypothetical protein	-
-	3681701..3682113	-	413	-	-	Antitoxin
KTP10_RS17915	3681848..3682123	+	276	WP_023232369.1	SymE family type I addiction module toxin	Toxin
KTP10_RS17920	3682180..3682512	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3669079..3704790	35711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9883.21 Da
• Isoelectric Point: 6.6996

>T207367 WP_023232369.1 NZ_CP077662:3681848-3682123 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

>T207367 NZ_CP102968:c2376242-2375976 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Nucleotide

• Length: 413 bp

>AT207367 NZ_CP077662:c3682113-3681701 [Salmonella enterica]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V8R754

Antitoxin