Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4527945..4528357 Replicon chromosome
Accession NZ_CP076404
Organism Escherichia coli strain K-12 substr. AB1157

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag KJY95_RS21900 Protein ID WP_000132601.1
Coordinates 4527945..4528286 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4528281..4528357 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJY95_RS21890 (4525358) 4525358..4526404 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
KJY95_RS21895 (4526404) 4526404..4527783 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
KJY95_RS21900 (4527945) 4527945..4528286 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4528281) 4528281..4528357 + 77 NuclAT_12 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_12 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_12 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_12 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_13 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_13 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_13 - Antitoxin
- (4528281) 4528281..4528357 + 77 NuclAT_13 - Antitoxin
KJY95_RS21905 (4528514) 4528514..4529908 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
KJY95_RS21910 (4529905) 4529905..4531494 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4520860..4529908 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T205650 WP_000132601.1 NZ_CP076404:c4528286-4527945 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T205650 NZ_CP101784:c4876859-4876575 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 77 bp

>AT205650 NZ_CP076404:4528281-4528357 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References