Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 3618008..3618223 | Replicon | chromosome |
| Accession | NZ_CP076401 | ||
| Organism | Clostridioides difficile strain S-0253 | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | KNZ77_RS16235 | Protein ID | WP_011861731.1 |
| Coordinates | 3618080..3618223 (-) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd12 | ||
| Locus tag | - | ||
| Coordinates | 3618008..3618154 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KNZ77_RS16210 (3613088) | 3613088..3613852 | - | 765 | WP_003432349.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| KNZ77_RS16215 (3613871) | 3613871..3614695 | - | 825 | WP_003432350.1 | phosphate ABC transporter permease PstA | - |
| KNZ77_RS16220 (3614697) | 3614697..3615614 | - | 918 | WP_004454007.1 | phosphate ABC transporter permease subunit PstC | - |
| KNZ77_RS16225 (3615995) | 3615995..3616441 | - | 447 | WP_016728508.1 | hypothetical protein | - |
| KNZ77_RS16230 (3617168) | 3617168..3617551 | - | 384 | WP_021391918.1 | BlaI/MecI/CopY family transcriptional regulator | - |
| - (3618008) | 3618008..3618154 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3618008) | 3618008..3618154 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3618008) | 3618008..3618154 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3618008) | 3618008..3618158 | + | 151 | NuclAT_1 | - | - |
| KNZ77_RS16235 (3618080) | 3618080..3618223 | - | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| KNZ77_RS16240 (3618482) | 3618482..3618670 | + | 189 | WP_009898401.1 | hypothetical protein | - |
| KNZ77_RS16245 (3619372) | 3619372..3619893 | + | 522 | WP_009898403.1 | ImmA/IrrE family metallo-endopeptidase | - |
| KNZ77_RS16250 (3619887) | 3619887..3621455 | + | 1569 | WP_009898404.1 | hypothetical protein | - |
| KNZ77_RS16255 (3621519) | 3621519..3622037 | - | 519 | WP_009898407.1 | DUF5706 domain-containing protein | - |
| KNZ77_RS16260 (3622203) | 3622203..3622550 | - | 348 | WP_009898409.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T205621 WP_011861731.1 NZ_CP076401:c3618223-3618080 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T205621 NZ_CP101775:133485-133634 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 147 bp
>AT205621 NZ_CP076401:3618008-3618154 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
