Detailed information of TA system TA205560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 314981..315201
• Replicon: chromosome
• Accession: NZ_CP076377
• Organism: Clostridioides difficile strain S-0352

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: A0A069AVC0
• Locus tag: KNZ78_RS01515
• Protein ID: WP_009901465.1
• Coordinates: 314981..315142 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	315062..315201 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNZ78_RS01465 (310093)	310093..310326	+	234	WP_003429842.1	hypothetical protein	-
KNZ78_RS01470 (310336)	310336..310737	+	402	WP_015984842.1	hypothetical protein	-
KNZ78_RS01475 (310731)	310731..311078	+	348	WP_015984843.1	hypothetical protein	-
KNZ78_RS01480 (311078)	311078..311503	+	426	WP_009896626.1	HK97 gp10 family phage protein	-
KNZ78_RS01485 (311496)	311496..311933	+	438	WP_009901457.1	hypothetical protein	-
KNZ78_RS01490 (311926)	311926..312102	+	177	WP_021368348.1	hypothetical protein	-
KNZ78_RS01495 (312103)	312103..313413	+	1311	WP_015984844.1	phage tail sheath family protein	-
KNZ78_RS01500 (313435)	313435..313905	+	471	WP_015984845.1	phage tail tube protein	-
KNZ78_RS01505 (313958)	313958..314215	+	258	WP_015984846.1	hypothetical protein	-
KNZ78_RS01510 (314220)	314220..314660	+	441	WP_015984847.1	hypothetical protein	-
KNZ78_RS01515 (314981)	314981..315142	+	162	WP_009901465.1	hypothetical protein	Toxin
- (315062)	315062..315201	-	140	NuclAT_3	-	Antitoxin
- (315062)	315062..315201	-	140	NuclAT_3	-	Antitoxin
- (315062)	315062..315201	-	140	NuclAT_4	-	Antitoxin
- (315062)	315062..315201	-	140	NuclAT_6	-	Antitoxin
- (315546)	315546..315651	-	106	NuclAT_11	-	-
- (315546)	315546..315651	-	106	NuclAT_6	-	-
- (315546)	315546..315651	-	106	NuclAT_6	-	-
- (315546)	315546..315651	-	106	NuclAT_9	-	-
KNZ78_RS01520 (316405)	316405..316593	+	189	WP_003429858.1	hypothetical protein	-
KNZ78_RS01525 (316712)	316712..317578	+	867	WP_021378510.1	BRO family protein	-
KNZ78_RS01530 (317631)	317631..317786	+	156	WP_021378513.1	hypothetical protein	-
KNZ78_RS01535 (318205)	318205..318417	-	213	WP_016728883.1	helix-turn-helix transcriptional regulator	-
KNZ78_RS19610 (318692)	318692..319471	+	780	WP_021391616.1	ORF6N domain-containing protein	-
KNZ78_RS01550 (319504)	319504..319656	+	153	WP_021378619.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6034.28 Da
• Isoelectric Point: 11.0253

>T205560 WP_009901465.1 NZ_CP076377:314981-315142 [Clostridioides difficile]
MDNFLLSILASLIASLIGYIVCRCIKNVKSHSTRGKSKSGWELGFKIKFRKFK

Nucleotide

• Length: 162 bp

>T205560 NZ_CP101740:2509247-2509501 [Sphingomonas qomolangmaensis]
ATGGAAAGCCTGAGCATCTCCGAAGCGCGCGCCAATATGAAGGCGGTCGTCGATCGCGTCGTCGCCGACAAGGCACCGGT
GGCGATCACCCGCCAGCGCGGTGAGGGCGTGGTGATGATATCGGCGAGCGAATGGGCGTCGATCGAGGAAACATTGTACC
TGCTGCAGTCGCCGGCGAACGCGCGCGCGCTGATCGAATCGATCGCCGAGCTGGACGCCGGCAAGGGTAGCGAGCGCGAC
CTGATCGCGCCGTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT205560 NZ_CP076377:c315201-315062 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGCGGTAGAGTGAAGTTCATAATTTTAAAAAATATAAATTATTTAAATTTGCGGAACTT
TATTTTAAAACCAAGTTCCCAGCCACTTTTACTCTTGCCACGAGTAGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVC0

Antitoxin