Detailed information of TA system TA205557

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2807767..2807976
• Replicon: chromosome
• Accession: NZ_CP076376
• Organism: Clostridioides difficile strain S-0942

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: Q182K5
• Locus tag: KNZ76_RS13185
• Protein ID: WP_004454815.1
• Coordinates: 2807818..2807976 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2807767..2807901 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNZ76_RS13170 (2803658)	2803658..2805286	+	1629	WP_004454813.1	aspartate 4-decarboxylase	-
KNZ76_RS13175 (2805407)	2805407..2806402	+	996	WP_003431031.1	asparaginase	-
KNZ76_RS19040 (2806591)	2806591..2806839	-	249	WP_231298879.1	BlaI/MecI/CopY family transcriptional regulator	-
- (2807767)	2807767..2807901	+	135	NuclAT_0	-	Antitoxin
- (2807767)	2807767..2807901	+	135	NuclAT_0	-	Antitoxin
- (2807767)	2807767..2807901	+	135	NuclAT_0	-	Antitoxin
KNZ76_RS13185 (2807818)	2807818..2807976	-	159	WP_004454815.1	hypothetical protein	Toxin
KNZ76_RS13190 (2808335)	2808335..2809705	-	1371	WP_021360826.1	cell wall-binding protein Cwp29	-
KNZ76_RS19050 (2810141)	2810141..2810227	+	87	WP_231298880.1	hypothetical protein	-
KNZ76_RS19055 (2810271)	2810271..2810570	-	300	WP_225555269.1	hypothetical protein	-
KNZ76_RS13205 (2810757)	2810757..2811029	+	273	WP_004454820.1	tyrosine-type recombinase/integrase	-
KNZ76_RS13210 (2811403)	2811403..2811483	-	81	Protein_2534	VOC family protein	-
KNZ76_RS13215 (2811523)	2811523..2812191	-	669	WP_009897711.1	VanZ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5996.20 Da
• Isoelectric Point: 11.3102

>T205557 WP_004454815.1 NZ_CP076376:c2807976-2807818 [Clostridioides difficile]
MDNFLQGILASLSASLIVYIASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T205557 NZ_CP101739:1989781-1990062 [Stutzerimonas stutzeri]
ATGCGGACGATTGAACAGACCAGCCGGTTCAAACGCGATTATAAACGCGAAGCCAAAGGCCCGCATCGTCAGACGCTGGC
GAGCGATTTCATTGCCGTCGTCACAGCCCTGGCGAATAACCAGCCTCTGGCCGAGAAGCACCGTGACCACGCCCTCACCG
GCGACTGGAAAGACCACCGGGACTGTCACATCAAGCCCGACCTGGTGTTGATTTACCGCAAGCCGGATGACGCCGTGCTG
CAACTCGTGCGTCTCGGATCGCATAGCGAGCTTGGCCTGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT205557 NZ_CP076376:2807767-2807901 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Toxin

• AlphaFold DB: A0A125V849

Antitoxin