Detailed information of TA system TA205551

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1525959..1526155
• Replicon: chromosome
• Accession: NZ_CP076376
• Organism: Clostridioides difficile strain S-0942

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: Q18BT8
• Locus tag: KNZ76_RS07220
• Protein ID: WP_009902496.1
• Coordinates: 1525959..1526111 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	1526055..1526155 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNZ76_RS07200 (1521498)	1521498..1522046	-	549	WP_011861206.1	DUF308 domain-containing protein	-
KNZ76_RS07205 (1522198)	1522198..1522626	+	429	WP_003429356.1	DMT family transporter	-
KNZ76_RS07210 (1522693)	1522693..1523361	+	669	WP_003429358.1	diphthine--ammonia ligase	-
KNZ76_RS07215 (1523479)	1523479..1524834	-	1356	WP_003438549.1	MATE family efflux transporter	-
KNZ76_RS07220 (1525959)	1525959..1526111	+	153	WP_009902496.1	hypothetical protein	Toxin
- (1526055)	1526055..1526155	-	101	NuclAT_2	-	Antitoxin
- (1526055)	1526055..1526155	-	101	NuclAT_2	-	Antitoxin
- (1526055)	1526055..1526155	-	101	NuclAT_2	-	Antitoxin
KNZ76_RS07225 (1527205)	1527205..1528938	-	1734	WP_074089699.1	sensor domain-containing diguanylate cyclase	-
KNZ76_RS07230 (1529178)	1529178..1530023	-	846	WP_009889222.1	c-di-GMP diguanylate cyclase DccA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5742.81 Da
• Isoelectric Point: 10.9178

>T205551 WP_009902496.1 NZ_CP076376:1525959-1526111 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Nucleotide

• Length: 153 bp

>T205551 NZ_CP101728:c140946-140641 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 101 bp

>AT205551 NZ_CP076376:c1526155-1526055 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGATGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A069ACY9

Antitoxin