Detailed information of TA system TA205548

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1272536..1272741
• Replicon: chromosome
• Accession: NZ_CP076376
• Organism: Clostridioides difficile strain S-0942

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: KNZ76_RS05935
• Protein ID: WP_009896140.1
• Coordinates: 1272536..1272688 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1272668..1272741 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNZ76_RS05915 (1267998)	1267998..1268282	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
KNZ76_RS05920 (1268305)	1268305..1269822	-	1518	WP_021360429.1	recombinase family protein	-
KNZ76_RS05925 (1269947)	1269947..1270768	-	822	WP_021360430.1	tetratricopeptide repeat protein	-
KNZ76_RS05930 (1270959)	1270959..1272386	+	1428	WP_021361414.1	cell wall-binding protein Cwp26	-
KNZ76_RS05935 (1272536)	1272536..1272688	+	153	WP_009896140.1	hypothetical protein	Toxin
- (1272668)	1272668..1272741	-	74	NuclAT_3	-	Antitoxin
- (1272668)	1272668..1272741	-	74	NuclAT_3	-	Antitoxin
- (1272668)	1272668..1272741	-	74	NuclAT_3	-	Antitoxin
KNZ76_RS05940 (1273568)	1273568..1273783	-	216	WP_021360433.1	helix-turn-helix transcriptional regulator	-
KNZ76_RS05945 (1274954)	1274954..1275109	+	156	WP_021360434.1	hypothetical protein	-
KNZ76_RS05950 (1275128)	1275128..1275484	-	357	WP_021360435.1	helix-turn-helix transcriptional regulator	-
KNZ76_RS05955 (1275647)	1275647..1275832	+	186	WP_021360436.1	hypothetical protein	-
KNZ76_RS05960 (1275952)	1275952..1276692	+	741	WP_021360437.1	Bro-N domain-containing protein	-
KNZ76_RS18960 (1276749)	1276749..1277342	+	594	WP_021360438.1	hypothetical protein	-
KNZ76_RS05970 (1277411)	1277411..1277629	+	219	WP_009894510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T205548 WP_009896140.1 NZ_CP076376:1272536-1272688 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T205548 NZ_CP101727:c143130-142714 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT205548 NZ_CP076376:c1272741-1272668 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin