204846

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2604689..2604914 Replicon chromosome
Accession NZ_CP076235
Organism Escherichia coli O157:H7 strain 9.1_Anguil

Toxin (Protein)


Gene name hokW Uniprot ID A0A1Q4PF16
Locus tag JKN68_RS13275 Protein ID WP_000813258.1
Coordinates 2604759..2604914 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2604689..2604747 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN68_RS13225 2599754..2599996 + 243 WP_000747948.1 Cro/CI family transcriptional regulator -
JKN68_RS13230 2599980..2600405 + 426 WP_000693878.1 toxin YdaT family protein -
JKN68_RS13235 2600474..2601517 + 1044 WP_001262402.1 DnaT-like ssDNA-binding domain-containing protein -
JKN68_RS13240 2601510..2601971 + 462 WP_000139447.1 replication protein P -
JKN68_RS13245 2602005..2602721 + 717 WP_000450627.1 DUF1627 domain-containing protein -
JKN68_RS13250 2602754..2603035 + 282 WP_000603384.1 DNA-binding protein -
JKN68_RS13255 2603032..2603259 + 228 WP_000699809.1 hypothetical protein -
JKN68_RS13260 2603252..2603563 + 312 WP_001289673.1 hypothetical protein -
JKN68_RS13265 2603691..2603909 + 219 WP_000683609.1 DUF4014 family protein -
JKN68_RS13270 2603911..2604468 + 558 WP_000104474.1 DUF551 domain-containing protein -
- 2604689..2604747 - 59 - - Antitoxin
JKN68_RS13275 2604759..2604914 + 156 WP_000813258.1 Hok/Gef family protein Toxin
JKN68_RS13280 2605034..2605378 + 345 WP_000756596.1 YgiW/YdeI family stress tolerance OB fold protein -
JKN68_RS13285 2605500..2605772 + 273 WP_000191872.1 hypothetical protein -
JKN68_RS13290 2605774..2606823 + 1050 WP_001265229.1 DUF968 domain-containing protein -
JKN68_RS13295 2606836..2607141 + 306 WP_001217444.1 RusA family crossover junction endodeoxyribonuclease -
JKN68_RS13300 2607204..2607758 + 555 WP_000640035.1 DUF1133 family protein -
JKN68_RS13305 2607983..2608180 + 198 WP_000917763.1 hypothetical protein -
JKN68_RS13310 2608316..2609029 + 714 WP_000301797.1 helix-turn-helix domain-containing protein -
JKN68_RS13325 2609480..2609911 + 432 WP_001302123.1 tellurite resistance protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2546213..2635368 89155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5767.95 Da        Isoelectric Point: 7.7942

>T204846 WP_000813258.1 NZ_CP076235:2604759-2604914 [Escherichia coli O157:H7]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Download         Length: 156 bp

>T204846 NZ_CP101269:859349-859756 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 59 bp

>AT204846 NZ_CP076235:c2604747-2604689 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4PF16

Antitoxin

Download structure file

References