Detailed information of TA system TA204225

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2107127..2107323
• Replicon: chromosome
• Accession: NZ_CP075685
• Organism: Clostridioides difficile strain MT5121

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: KK112_RS09955
• Protein ID: WP_003424190.1
• Coordinates: 2107171..2107323 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	2107127..2107227 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KK112_RS09940 (2102394)	2102394..2102651	-	258	WP_003424182.1	hypothetical protein	-
KK112_RS09945 (2102638)	2102638..2102871	-	234	WP_003424184.1	hypothetical protein	-
KK112_RS09950 (2103059)	2103059..2103247	+	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
KK112_RS18515 (2103450)	2103450..2103581	-	132	WP_003424186.1	hypothetical protein	-
- (2107127)	2107127..2107227	+	101	NuclAT_0	-	Antitoxin
- (2107127)	2107127..2107227	+	101	NuclAT_0	-	Antitoxin
- (2107127)	2107127..2107227	+	101	NuclAT_0	-	Antitoxin
KK112_RS09955 (2107171)	2107171..2107323	-	153	WP_003424190.1	hypothetical protein	Toxin
KK112_RS09960 (2108166)	2108166..2108696	+	531	WP_003424192.1	site-specific integrase	-
KK112_RS09965 (2109241)	2109241..2110086	+	846	WP_003424194.1	DUF4878 domain-containing protein	-
KK112_RS09970 (2110310)	2110310..2110474	-	165	WP_003424195.1	hypothetical protein	-
KK112_RS18370 (2111006)	2111006..2111197	-	192	WP_003424196.1	carboxymuconolactone decarboxylase family protein	-
KK112_RS18375 (2111197)	2111197..2111337	-	141	WP_003424197.1	hypothetical protein	-
KK112_RS09980 (2111597)	2111597..2112238	-	642	WP_003424198.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T204225 WP_003424190.1 NZ_CP075685:c2107323-2107171 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T204225 NZ_CP100678:316026-316394 [Salmonella enterica subsp. enterica serovar Anatum]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT204225 NZ_CP075685:2107127-2107227 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin