Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 1784480..1785086 | Replicon | chromosome |
| Accession | NC_002754 | ||
| Organism | Sulfolobus solfataricus P2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q97WY9 |
| Locus tag | SSO_RS09600 | Protein ID | WP_009991922.1 |
| Coordinates | 1784694..1785086 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | C3NC15 |
| Locus tag | SSO_RS09595 | Protein ID | WP_009991920.1 |
| Coordinates | 1784480..1784704 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SSO_RS09560 (SSO1966) | 1779715..1780665 | - | 951 | WP_010923701.1 | IS110 family transposase | - |
| SSO_RS09565 (SSO9368) | 1780824..1781108 | + | 285 | Protein_1909 | IS607-like element ISC1913 family transposase | - |
| SSO_RS09570 (SSO1967) | 1781092..1782312 | + | 1221 | WP_014511730.1 | IS200/IS605 family accessory protein TnpB-related protein | - |
| SSO_RS09575 (SSO1968) | 1782460..1782846 | - | 387 | WP_009991912.1 | type II toxin-antitoxin system VapC family toxin | - |
| SSO_RS09580 (SSO9378) | 1782833..1783108 | - | 276 | WP_009991915.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SSO_RS09585 | 1783479..1783715 | + | 237 | WP_009991916.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| SSO_RS09590 (SSO1969) | 1783693..1784091 | + | 399 | WP_009991918.1 | type II toxin-antitoxin system VapC family toxin | - |
| SSO_RS09595 | 1784480..1784704 | + | 225 | WP_009991920.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| SSO_RS09600 (SSO1970) | 1784694..1785086 | + | 393 | WP_009991922.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| SSO_RS09605 | 1785260..1786205 | + | 946 | Protein_1917 | IS110 family transposase | - |
| SSO_RS09610 (SSO1974) | 1786309..1787457 | - | 1149 | WP_010923706.1 | RNA-guided endonuclease TnpB family protein | - |
| SSO_RS09615 (SSO1975) | 1787734..1788111 | - | 378 | WP_009989379.1 | type II toxin-antitoxin system VapC family toxin | - |
| SSO_RS09620 | 1788077..1788331 | - | 255 | WP_009989377.1 | antitoxin VapB family protein | - |
| SSO_RS09625 (SSO1976) | 1788560..1788904 | - | 345 | WP_009989373.1 | heavy metal-binding domain-containing protein | - |
| SSO_RS09630 (SSO1977) | 1789208..1789606 | - | 399 | WP_009989371.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | IScluster/Tn | - | - | 1779283..1791979 | 12696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 15105.86 Da Isoelectric Point: 8.2957
>T20405 WP_009991922.1 NC_002754:1784694-1785086 [Saccharolobus solfataricus P2]
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
MKDKEFLFDASALYSLLDYVDKIDLKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSMLFHKLMRKLNIVEDPPLEGV
MRIAVERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM
Download Length: 393 bp
>T20405 NC_002754:1784694-1785086 [Saccharolobus solfataricus P2]
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
ATGAAAGATAAGGAATTCCTATTCGATGCCTCAGCTTTGTACTCGCTTTTAGATTACGTGGATAAAATAGACTTAAAGAA
AATTCATATACTTACCCTAACTTTTTATGAGGTAGGTAACGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACTCTTTCGATGCTTTTCCATAAATTAATGCGAAAACTTAACATAGTAGAGGATCCACCTCTTGAGGGAGTA
ATGAGAATTGCCGTAGAAAGGGGTTTGACTTACTATGACGCATCTTATGCATATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGCTGATAAGAAAAGCTAATGCTATTTCATTAAAAGATTTGATAAAAAGTATGTGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8881.24 Da Isoelectric Point: 5.0355
>AT20405 WP_009991920.1 NC_002754:1784480-1784704 [Saccharolobus solfataricus P2]
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
MSDVISVRVKKELKKRAEELGINIREVVEKALEEAIREKEKEELKDIVMRIKELMRDVSEDDWVRAVRESRDER
Download Length: 225 bp
>AT20405 NC_002754:1784480-1784704 [Saccharolobus solfataricus P2]
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
ATGTCAGACGTAATAAGCGTAAGGGTTAAGAAAGAGCTGAAGAAGAGGGCAGAGGAGTTGGGAATTAACATTAGGGAAGT
TGTAGAAAAAGCTTTAGAAGAGGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATAGTTATGAGAATTAAGGAAC
TAATGAGAGATGTAAGTGAAGATGATTGGGTAAGGGCTGTTAGGGAGAGTAGGGATGAAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3K6Y2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E3MHL6 |