Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1073702..1074308 Replicon chromosome
Accession NC_002754
Organism Sulfolobus solfataricus P2

Toxin (Protein)


Gene name vapC Uniprot ID Q97YS3
Locus tag SSO_RS06095 Protein ID WP_009993017.1
Coordinates 1073916..1074308 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3G8ES43
Locus tag SSO_RS06090 Protein ID WP_009993015.1
Coordinates 1073702..1073926 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSO_RS06065 (SSO1233) 1068850..1069980 + 1131 WP_009992604.1 aromatic/alkene monooxygenase hydroxylase subunit beta -
SSO_RS06070 (SSO1234) 1069977..1070438 + 462 WP_010923265.1 metal-sulfur cluster assembly factor -
SSO_RS06075 1070481..1071396 - 916 Protein_1194 IS110 family transposase -
SSO_RS06080 (SSO1238) 1071441..1072424 + 984 WP_010923242.1 IS630-like element ISC1048 family transposase -
SSO_RS06085 1072423..1073392 + 970 Protein_1196 IS110 family transposase -
SSO_RS06090 1073702..1073926 + 225 WP_009993015.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SSO_RS06095 (SSO1243) 1073916..1074308 + 393 WP_009993017.1 type II toxin-antitoxin system VapC family toxin Toxin
SSO_RS16130 1074751..1075229 - 479 Protein_1199 ISNCY family transposase -
SSO_RS06110 (SSO1245) 1075347..1076399 + 1053 WP_010923271.1 ISH3 family transposase -
SSO_RS06115 (SSO1250) 1076587..1077174 - 588 Protein_1201 ISNCY family transposase -
SSO_RS06120 (SSO1251) 1077608..1077949 - 342 WP_009990179.1 nucleotidyltransferase domain-containing protein -
SSO_RS06125 (SSO1252) 1077940..1078287 - 348 WP_014511635.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 1070884..1077174 6290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Post-segregation antitoxin CcdA

(5-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15117.81 Da        Isoelectric Point: 9.3474

>T20399 WP_009993017.1 NC_002754:1073916-1074308 [Saccharolobus solfataricus P2]
MKDKEFLLDASALYSLLDYVDKVDVKKIHVLTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVIEDSPLEGV
MRIAIERGLTYYNASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T20399 NC_002754:1073916-1074308 [Saccharolobus solfataricus P2]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8840.20 Da        Isoelectric Point: 5.0190

>AT20399 WP_009993015.1 NC_002754:1073702-1073926 [Saccharolobus solfataricus P2]
MSDVISVRVKKELKKKAEELGINVREVVEKALEEAIREKEKEELKDMTMKIKELMRDVSEYDWVSTVRESRDER

Download         Length: 225 bp

>AT20399 NC_002754:1073702-1073926 [Saccharolobus solfataricus P2]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAATATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3GVD1

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8ES43

References