Detailed information of TA system TA203227

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3719986..3720388
• Replicon: chromosome
• Accession: NZ_CP075137
• Organism: Salmonella enterica strain CFSAN044885

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9E7A9
• Locus tag: A7S07_RS18165
• Protein ID: WP_023216760.1
• Coordinates: 3720143..3720388 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3719986..3720352 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S07_RS18140	3716381..3716977	+	597	Protein_3560	ATP-binding protein	-
A7S07_RS18145	3717017..3717203	-	187	Protein_3561	transposase	-
A7S07_RS18150	3717256..3717504	+	249	WP_023216986.1	SymE family type I addiction module toxin	-
A7S07_RS18155	3717636..3717913	-	278	Protein_3563	hypothetical protein	-
A7S07_RS18160	3718231..3718698	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
-	3719986..3720352	-	367	-	-	Antitoxin
A7S07_RS18165	3720143..3720388	+	246	WP_023216760.1	hypothetical protein	Toxin
A7S07_RS18170	3720447..3720755	-	309	WP_023216761.1	hypothetical protein	-
A7S07_RS18175	3720774..3721151	-	378	WP_024147216.1	DUF4329 domain-containing protein	-
A7S07_RS18180	3721542..3722063	-	522	WP_023203424.1	SMI1/KNR4 family protein	-
A7S07_RS23710	3722077..3722157	-	81	WP_079940869.1	HNH endonuclease	-
A7S07_RS18185	3722458..3723270	-	813	Protein_3570	RHS domain-containing protein	-
A7S07_RS18190	3723412..3723993	-	582	WP_249265070.1	hypothetical protein	-
A7S07_RS23715	3723996..3724256	-	261	WP_023216764.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3707225..3728327	21102

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8791.93 Da
• Isoelectric Point: 4.1428

>T203227 WP_023216760.1 NZ_CP075137:3720143-3720388 [Salmonella enterica]
MNASGASVRHINSETCMTTCYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T203227 NZ_CP099896:110955-111476 [Escherichia albertii]
GTGAGCAATACAACGATAGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCCTTTTTAGCCAACCACTTAAAAAGGCAGCATGAGGGAAAAATTCTTCGTGCTTATGTGCTTTGCACTCAAGAAG
AAAGGCCAAAAGTGTTAGGATATTACACTTTGTCAGGTAGTTGTTTTGAAAAGGAGTCCTTACCTTCAAGAAGCAAACAA
AAGAAGGTTCCTTATCGGAATGTTCCAAGTGTTACTTTGGGTAGGCTGGCTTTGGACAAGTCCCTTCAAGGTCAAGGATT
TGGCTCAATGCTTGTAACACATGCAATGCGCGTTGTGTACAATGCATCTCTTGCTGTAGGCATTCATGGACTTTTCGTTG
AGGCGTTAAATGACAAAGCCAAGGCGTTTTATAAAAGTTTAGGCTTTATCCAGCTGGTTGGTAACAACGAGCGTTCTTTG
TTCTATCCTACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin

Nucleotide

• Length: 367 bp

>AT203227 NZ_CP075137:c3720352-3719986 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCG
GCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9E7A9

Antitoxin