Detailed information of TA system TA202880

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3639321..3639671
• Replicon: chromosome
• Accession: NZ_CP075109
• Organism: Salmonella enterica strain CFSAN060807

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: CIC24_RS17770
• Protein ID: WP_000994229.1
• Coordinates: 3639414..3639671 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3639321..3639589 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC24_RS17730	3634361..3635065	-	705	Protein_3485	integrase core domain-containing protein	-
CIC24_RS17735	3635118..3635366	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
CIC24_RS17740	3635498..3635776	-	279	WP_079798501.1	hypothetical protein	-
CIC24_RS23100	3635859..3635975	-	117	WP_227457392.1	hypothetical protein	-
CIC24_RS17750	3636217..3636474	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
CIC24_RS17755	3636565..3636942	-	378	WP_000739707.1	Imm8 family immunity protein	-
CIC24_RS17760	3637675..3638040	-	366	WP_001231281.1	hypothetical protein	-
CIC24_RS17765	3638006..3639352	-	1347	Protein_3492	RHS domain-containing protein	-
-	3639321..3639589	-	269	-	-	Antitoxin
CIC24_RS17770	3639414..3639671	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
CIC24_RS17775	3639735..3640073	-	339	WP_000382983.1	hypothetical protein	-
CIC24_RS17780	3640444..3642201	-	1758	Protein_3495	RHS repeat protein	-
CIC24_RS17785	3642406..3642639	+	234	WP_000035941.1	hypothetical protein	-
CIC24_RS17790	3642711..3643058	-	348	WP_000887296.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3615873..3643082	27209
	-	flank	IS/Tn	-	-	3634361..3634642	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T202880 WP_000994229.1 NZ_CP075109:3639414-3639671 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T202880 NZ_CP075109:3639414-3639671 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCACCTTAAGGGTGACTGGCTGGAAGAAGCGGGATTTGAGACCGGGCGCGGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin

Nucleotide

• Length: 269 bp

>AT202880 NZ_CP075109:c3639589-3639321 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin