Detailed information of TA system TA202877

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3636060..3636474
• Replicon: chromosome
• Accession: NZ_CP075109
• Organism: Salmonella enterica strain CFSAN060807

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: CIC24_RS17750
• Protein ID: WP_079798500.1
• Coordinates: 3636217..3636474 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3636060..3636392 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC24_RS17720	3632289..3633026	-	738	WP_001750707.1	pili assembly chaperone SafB	-
CIC24_RS17725	3633103..3633600	-	498	WP_001750706.1	Saf-pilin pilus formation protein SafA	-
CIC24_RS17730	3634361..3635065	-	705	Protein_3485	integrase core domain-containing protein	-
CIC24_RS17735	3635118..3635366	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
CIC24_RS17740	3635498..3635776	-	279	WP_079798501.1	hypothetical protein	-
CIC24_RS23100	3635859..3635975	-	117	WP_227457392.1	hypothetical protein	-
-	3636060..3636392	-	333	-	-	Antitoxin
CIC24_RS17750	3636217..3636474	+	258	WP_079798500.1	SymE family type I addiction module toxin	Toxin
CIC24_RS17755	3636565..3636942	-	378	WP_000739707.1	Imm8 family immunity protein	-
CIC24_RS17760	3637675..3638040	-	366	WP_001231281.1	hypothetical protein	-
CIC24_RS17765	3638006..3639352	-	1347	Protein_3492	RHS domain-containing protein	-
CIC24_RS17770	3639414..3639671	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
CIC24_RS17775	3639735..3640073	-	339	WP_000382983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3615873..3643082	27209
	-	flank	IS/Tn	-	-	3634361..3634642	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9547.82 Da
• Isoelectric Point: 5.0770

>T202877 WP_079798500.1 NZ_CP075109:3636217-3636474 [Salmonella enterica]
MNASGVSVRHINSETCMSACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T202877 NZ_CP099734:c2850232-2849846 [Photobacterium sp. TY1-4]
ATGGCGTCGTTGATTGCATATATGAATGGTGAATGTGTTGGGAAGTTGATCAAGCTCGCTGATGGCGCTCATCACTTTCA
ATATGCCGAAGAGTGGATAGAAAGCCCAAGAGGAAGGCCTTTGTCTCTGTCTTTGCCGCTTCAGTATCAAAAGCTCACTT
CAAATTGTGTTATCAACTATTTTGATAACCTTTTACCAGATCTGAATGAAATCAGGGATCGTATCGTTGCTCGCTACAAT
GCCGATTCAAGGCAAGCGTTTGACCTGTTGAAACAAGTCGGTAAAGACAGTGTTGGTGCCATTTCACTACATATGCCAGA
AGAGCGTCCCGCTCCAAAACAGCTGGAATATGAAGTATTAGATGACCGCAGATTAAAGGATGAATAG

Antitoxin

Nucleotide

• Length: 333 bp

>AT202877 NZ_CP075109:c3636392-3636060 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Antitoxin