Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2655084..2655692 Replicon chromosome
Accession NC_002488
Organism Xylella fastidiosa 9a5c

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag XF_RS12000 Protein ID WP_196432211.1
Coordinates 2655396..2655692 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9P9V8
Locus tag XF_RS11995 Protein ID WP_010895177.1
Coordinates 2655084..2655392 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XF_RS11965 (XF2760) 2651668..2652429 - 762 WP_010895174.1 Bax inhibitor-1/YccA family protein -
XF_RS14745 2653230..2653424 + 195 WP_069107173.1 hypothetical protein -
XF_RS11990 (XF2762) 2653624..2655018 + 1395 WP_010895176.1 hypothetical protein -
XF_RS11995 (XF2763) 2655084..2655392 - 309 WP_010895177.1 putative addiction module antidote protein Antitoxin
XF_RS12000 (XF2764) 2655396..2655692 - 297 WP_196432211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XF_RS12005 (XF2765) 2655779..2656549 + 771 WP_010895179.1 hypothetical protein -
XF_RS12010 (XF2766) 2656549..2656815 + 267 WP_010895180.1 hypothetical protein -
XF_RS12015 (XF2768) 2657274..2657667 - 394 Protein_2367 DUF596 domain-containing protein -
XF_RS12020 (XF2769) 2657679..2658029 - 351 Protein_2368 DUF769 domain-containing protein -
XF_RS12025 (XF2770) 2658207..2658590 - 384 WP_031338086.1 DUF596 domain-containing protein -
XF_RS12030 (XF2771) 2658602..2658931 - 330 WP_195780013.1 DUF769 domain-containing protein -
XF_RS12035 (XF2772) 2659103..2659495 - 393 WP_031338089.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2653624..2656815 3191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11317.07 Da        Isoelectric Point: 10.1713

>T20287 WP_196432211.1 NC_002488:c2655692-2655396 [Xylella fastidiosa 9a5c]
IYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDKS
TQQSDIRRAIELAKSLED

Download         Length: 297 bp

>T20287 NC_002488:c2655692-2655396 [Xylella fastidiosa 9a5c]
ATCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCTCAT
CAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGCGCGAAC
ACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAGTCA
ACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11038.60 Da        Isoelectric Point: 4.6561

>AT20287 WP_010895177.1 NC_002488:c2655392-2655084 [Xylella fastidiosa 9a5c]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Download         Length: 309 bp

>AT20287 NC_002488:c2655392-2655084 [Xylella fastidiosa 9a5c]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V409

References