Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2657120..2657731 Replicon chromosome
Accession NZ_CP009790
Organism Xylella fastidiosa strain U24d

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag XFUD_RS12845 Protein ID WP_023907140.1
Coordinates 2657432..2657731 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9P9V8
Locus tag XFUD_RS12840 Protein ID WP_010895177.1
Coordinates 2657120..2657428 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFUD_RS12805 2653704..2654465 - 762 WP_010895174.1 Bax inhibitor-1/YccA family protein -
XFUD_RS12835 2655660..2657054 + 1395 WP_010895176.1 hypothetical protein -
XFUD_RS12840 2657120..2657428 - 309 WP_010895177.1 putative addiction module antidote protein Antitoxin
XFUD_RS12845 2657432..2657731 - 300 WP_023907140.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFUD_RS12850 2657815..2658585 + 771 WP_010895179.1 hypothetical protein -
XFUD_RS12855 2658585..2658851 + 267 WP_010895180.1 hypothetical protein -
XFUD_RS12860 2659310..2659599 - 290 Protein_2344 DUF596 domain-containing protein -
XFUD_RS12865 2659714..2660064 - 351 Protein_2345 DUF769 domain-containing protein -
XFUD_RS12870 2660242..2660625 - 384 WP_031338086.1 DUF596 domain-containing protein -
XFUD_RS12875 2660637..2660966 - 330 WP_195780013.1 DUF769 domain-containing protein -
XFUD_RS12880 2661138..2661530 - 393 WP_031338089.1 DUF596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2655660..2658851 3191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11448.26 Da        Isoelectric Point: 10.1713

>T49824 WP_023907140.1 NZ_CP009790:c2657731-2657432 [Xylella fastidiosa]
MIYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T49824 NZ_CP009790:c2657731-2657432 [Xylella fastidiosa]
ATGATCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGACAAG
TCAACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11038.60 Da        Isoelectric Point: 4.6561

>AT49824 WP_010895177.1 NZ_CP009790:c2657428-2657120 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Download         Length: 309 bp

>AT49824 NZ_CP009790:c2657428-2657120 [Xylella fastidiosa]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V409

References