Detailed information of TA system TA049914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2726127..2726741
• Replicon: chromosome
• Accession: NZ_CP009829
• Organism: Xylella fastidiosa strain 3124

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XFC3_RS12335
• Protein ID: WP_088572660.1
• Coordinates: 2726439..2726741 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9P9V8
• Locus tag: XFC3_RS12330
• Protein ID: WP_010895177.1
• Coordinates: 2726127..2726435 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFC3_RS12300	2722708..2723469	-	762	WP_010895174.1	Bax inhibitor-1/YccA family protein	-
XFC3_RS12325	2724664..2726061	+	1398	WP_088572659.1	hypothetical protein	-
XFC3_RS12330	2726127..2726435	-	309	WP_010895177.1	putative addiction module antidote protein	Antitoxin
XFC3_RS12335	2726439..2726741	-	303	WP_088572660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFC3_RS12340	2726825..2727595	+	771	WP_010895179.1	hypothetical protein	-
XFC3_RS12345	2727595..2727861	+	267	WP_023907141.1	hypothetical protein	-
XFC3_RS12350	2728320..2728714	-	395	Protein_2411	DUF596 domain-containing protein	-
XFC3_RS12355	2728726..2729076	-	351	Protein_2412	DUF769 domain-containing protein	-
XFC3_RS12360	2729254..2729637	-	384	WP_031338086.1	DUF596 domain-containing protein	-
XFC3_RS12365	2729649..2729978	-	330	WP_195780013.1	DUF769 domain-containing protein	-
XFC3_RS12370	2730150..2730542	-	393	WP_031338089.1	DUF596 domain-containing protein	-
XFC3_RS12375	2730553..2730803	-	251	Protein_2416	hemagglutinin	-
XFC3_RS12380	2730957..2731151	-	195	WP_088572661.1	DUF769 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002488 Xylella fastidiosa 9a5c Prophage TA020287 2653624..2656815 0.001	inside	Prophage	-	-	2724664..2727861	3197

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-96)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11595.43 Da
• Isoelectric Point: 10.1713

>T49914 WP_088572660.1 NZ_CP009829:c2726741-2726439 [Xylella fastidiosa]
MIYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLFGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGD
KSTQQSDIRRAIELAKSLED

Nucleotide

• Length: 303 bp

>T49914 NZ_CP009829:c2726741-2726439 [Xylella fastidiosa]
ATGATCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCTTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGC
GCGAACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGAC
AAGTCAACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11038.60 Da
• Isoelectric Point: 4.6561

>AT49914 WP_010895177.1 NZ_CP009829:c2726435-2726127 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Nucleotide

• Length: 309 bp

>AT49914 NZ_CP009829:c2726435-2726127 [Xylella fastidiosa]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S0V409