Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2726127..2726741 Replicon chromosome
Accession NZ_CP009829
Organism Xylella fastidiosa strain 3124

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag XFC3_RS12335 Protein ID WP_088572660.1
Coordinates 2726439..2726741 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9P9V8
Locus tag XFC3_RS12330 Protein ID WP_010895177.1
Coordinates 2726127..2726435 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFC3_RS12300 2722708..2723469 - 762 WP_010895174.1 Bax inhibitor-1/YccA family protein -
XFC3_RS12325 2724664..2726061 + 1398 WP_088572659.1 hypothetical protein -
XFC3_RS12330 2726127..2726435 - 309 WP_010895177.1 putative addiction module antidote protein Antitoxin
XFC3_RS12335 2726439..2726741 - 303 WP_088572660.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFC3_RS12340 2726825..2727595 + 771 WP_010895179.1 hypothetical protein -
XFC3_RS12345 2727595..2727861 + 267 WP_023907141.1 hypothetical protein -
XFC3_RS12350 2728320..2728714 - 395 Protein_2411 DUF596 domain-containing protein -
XFC3_RS12355 2728726..2729076 - 351 Protein_2412 DUF769 domain-containing protein -
XFC3_RS12360 2729254..2729637 - 384 WP_031338086.1 DUF596 domain-containing protein -
XFC3_RS12365 2729649..2729978 - 330 WP_195780013.1 DUF769 domain-containing protein -
XFC3_RS12370 2730150..2730542 - 393 WP_031338089.1 DUF596 domain-containing protein -
XFC3_RS12375 2730553..2730803 - 251 Protein_2416 hemagglutinin -
XFC3_RS12380 2730957..2731151 - 195 WP_088572661.1 DUF769 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2724664..2727861 3197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-96)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11595.43 Da        Isoelectric Point: 10.1713

>T49914 WP_088572660.1 NZ_CP009829:c2726741-2726439 [Xylella fastidiosa]
MIYTVKRLEEFSDWLKGLKDGLARQRLIKRLRKVQLFGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGD
KSTQQSDIRRAIELAKSLED

Download         Length: 303 bp

>T49914 NZ_CP009829:c2726741-2726439 [Xylella fastidiosa]
ATGATCTACACGGTGAAACGACTCGAAGAGTTCTCTGACTGGCTAAAGGGCCTGAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCTTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAGATGC
GCGAACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGTGGCGGCGAC
AAGTCAACGCAACAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTGGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11038.60 Da        Isoelectric Point: 4.6561

>AT49914 WP_010895177.1 NZ_CP009829:c2726435-2726127 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLSSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREGLYKALRPGSEP
RFDTISRVCTALGIRLVAQPMR

Download         Length: 309 bp

>AT49914 NZ_CP009829:c2726435-2726127 [Xylella fastidiosa]
GTGACCATCACCAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAGCAGCGAGGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTGGGTGACATTGCCCGTTCAC
GTGGCATGTCTCAGATTGCGAAGGATTCCGGCATCACGCGGGAAGGTCTATACAAGGCCCTTCGGCCTGGCAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTCGGTATACGTCTAGTAGCGCAACCAATGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S0V409

References