Detailed information of TA system TA202855

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3553907..3554321
• Replicon: chromosome
• Accession: NZ_CP075108
• Organism: Salmonella enterica strain CFSAN060808

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: CIC23_RS17275
• Protein ID: WP_220541963.1
• Coordinates: 3554064..3554321 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3553907..3554239 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC23_RS17245	3550135..3550872	-	738	WP_220541961.1	pili assembly chaperone SafB	-
CIC23_RS17250	3550949..3551446	-	498	WP_220541962.1	Saf-pilin pilus formation protein SafA	-
CIC23_RS17255	3552210..3552911	-	702	Protein_3397	integrase core domain-containing protein	-
CIC23_RS17260	3552964..3553278	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
CIC23_RS17265	3553345..3553623	-	279	WP_077677834.1	hypothetical protein	-
CIC23_RS22565	3553706..3553822	-	117	WP_259398730.1	hypothetical protein	-
-	3553907..3554239	-	333	-	-	Antitoxin
CIC23_RS17275	3554064..3554321	+	258	WP_220541963.1	SymE family type I addiction module toxin	Toxin
CIC23_RS17280	3554385..3554723	-	339	WP_000382983.1	hypothetical protein	-
CIC23_RS17285	3555094..3556851	-	1758	Protein_3403	RHS repeat protein	-
CIC23_RS17290	3557056..3557289	+	234	WP_000035941.1	hypothetical protein	-
CIC23_RS17295	3557361..3557708	-	348	WP_000887296.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3545881..3557732	11851
	-	flank	IS/Tn	-	-	3552210..3552488	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9518.95 Da
• Isoelectric Point: 9.5752

>T202855 WP_220541963.1 NZ_CP075108:3554064-3554321 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
RDVIV

Nucleotide

• Length: 258 bp

>T202855 NZ_CP099721:2499406-2499684 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT202855 NZ_CP075108:c3554239-3553907 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Antitoxin