Detailed information of TA system TA202836

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3415176..3415590
• Replicon: chromosome
• Accession: NZ_CP075107
• Organism: Salmonella enterica strain CFSAN060809

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: CIC22_RS16440
• Protein ID: WP_000994230.1
• Coordinates: 3415333..3415590 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3415176..3415508 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CIC22_RS16410	3410436..3410930	-	495	WP_220541815.1	pilus assembly protein	-
CIC22_RS16415	3411694..3412395	-	702	Protein_3229	integrase core domain-containing protein	-
CIC22_RS16420	3412448..3412762	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
CIC22_RS16425	3412829..3413107	-	279	WP_077906417.1	hypothetical protein	-
CIC22_RS16430	3413425..3413892	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
CIC22_RS16435	3414765..3414998	-	234	WP_139377220.1	hypothetical protein	-
-	3415176..3415508	-	333	-	-	Antitoxin
CIC22_RS16440	3415333..3415590	+	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
CIC22_RS16445	3415656..3416102	-	447	WP_000171102.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	gmhA/lpcA	3362383..3423510	61127
	-	flank	IS/Tn	-	-	3411694..3411972	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T202836 WP_000994230.1 NZ_CP075107:3415333-3415590 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T202836 NZ_CP099713:c14263-14006 [Dietzia kunjamensis]
GTGCTGCTCGTCTGGGACGACAACGCCTGGCAGGACTACCTCTGGTGGCAACAGCAGGACCGCAAGATCCTCAAGCGCAT
CAACCTGCTCCTGCAGGACATCACCCGCAACGGCAATGAAGGAATCGGCAAACCCGAACCCCTCAAATACGACTTCGCCG
GATACTGGTCCAGACGCATCACCGACGAGCACCGGCTCGTCTACAAAGTCACCGACACGGAAGTCCGTATCGCCACCTGC
CGCTACCACTACGGGTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT202836 NZ_CP075107:c3415508-3415176 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGACAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin