Detailed information of TA system TA202816

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3688314..3688728
• Replicon: chromosome
• Accession: NZ_CP075106
• Organism: Salmonella enterica strain CFSAN064276

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: CBI76_RS18030
• Protein ID: WP_023243487.1
• Coordinates: 3688471..3688728 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3688314..3688646 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBI76_RS18000	3683582..3684076	-	495	WP_023228257.1	Saf-pilin pilus formation protein SafA	-
CBI76_RS18005	3684832..3685536	-	705	Protein_3544	integrase core domain-containing protein	-
CBI76_RS18010	3685589..3685903	+	315	WP_072101091.1	SymE family type I addiction module toxin	-
CBI76_RS18015	3685970..3686248	-	279	WP_012543321.1	hypothetical protein	-
CBI76_RS18020	3686564..3687031	-	468	WP_023244346.1	hypothetical protein	-
CBI76_RS18025	3687904..3688137	-	234	WP_125462689.1	hypothetical protein	-
-	3688314..3688646	-	333	-	-	Antitoxin
CBI76_RS18030	3688471..3688728	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
CBI76_RS18035	3688787..3689095	-	309	WP_023216761.1	hypothetical protein	-
CBI76_RS18040	3689113..3689490	-	378	WP_024149347.1	DUF4329 domain-containing protein	-
CBI76_RS18045	3689881..3690402	-	522	WP_023243488.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3675063..3690402	15339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T202816 WP_023243487.1 NZ_CP075106:3688471-3688728 [Salmonella enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T202816 NZ_CP099647:3777567-3777848 [Paraburkholderia fungorum]
ATGATCACGACATTCGGCGACAAGGCTACGGCAGCAATCTTCCACGGCAAGTTCGTGCATTCACTGCCGCTCTACATGCA
GGCGCTCGCACGCCGCAAGCTGCTGATGATCGATGCCGCGGAGTCCATCCGCAGCCTGCATGCGCCGCCGGGCAACCGGC
TCGAAGCCTTGCAAGGCCAGCGCAGCGGGCAGTGGAGCATTCGCATCAACGCGCAGTGGCGCATCTGTTTTCATTTTGTC
GACGGGGAGACGCTGAATGTCGAAATTGTCGACTATCACTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT202816 NZ_CP075106:c3688646-3688314 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin