Detailed information of TA system TA202529

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3722979..3723411
• Replicon: chromosome
• Accession: NZ_CP074606
• Organism: Salmonella enterica subsp. enterica serovar Newport str. CFSAN000827

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: DLM99_RS18360
• Protein ID: WP_000994224.1
• Coordinates: 3723136..3723411 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3722979..3723401 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLM99_RS18330	3718764..3719504	-	741	WP_000691919.1	pili assembly chaperone SafB	-
DLM99_RS18335	3719579..3720076	-	498	WP_000526848.1	hypothetical protein	-
DLM99_RS18340	3720206..3720700	-	495	WP_000786171.1	hypothetical protein	-
DLM99_RS18345	3721284..3721985	-	702	Protein_3616	integrase core domain-containing protein	-
DLM99_RS18350	3722038..3722286	+	249	WP_077906239.1	SymE family type I addiction module toxin	-
DLM99_RS18355	3722418..3722696	-	279	WP_077906242.1	hypothetical protein	-
-	3722979..3723401	-	423	-	-	Antitoxin
DLM99_RS18360	3723136..3723411	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
DLM99_RS18365	3723464..3723874	-	411	WP_001286802.1	immunity 26/phosphotriesterase HocA family protein	-
DLM99_RS18370	3724393..3724839	-	447	WP_000935097.1	protein SciX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3711690..3746737	35047
	-	flank	IS/Tn	-	-	3721284..3721562	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T202529 WP_000994224.1 NZ_CP074606:3723136-3723411 [Salmonella enterica subsp. enterica serovar Newport str.]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T202529 NZ_CP099490:3571395-3571709 [Ornithinimicrobium cryptoxanthini]
ATGCGTGAAATCTGCCTGGCCCGGCTCGACAAGACGCGCCCGGTGCTGGTGCTGACCCGGGAGGCGACCAGGGGCACGAT
GACCAAGGTCACCGTCGCCCCGATCACTTCCACGGTCAAGGGCCTCGCGAGCGAGCTCCCTGTCGGACCCGGCAACGGAC
TTGAGCACCCCTGCGCCGTCTCGCTCGACAACGTCCTCACCATCCGCTCGGAACTCCTTGGTCGCACCATCGGCTTCCTC
CATGACCGCGAGGAGCCCGCACTGGCACGCGCCATCGTCATGGCCTACGACCTGGACGTGCCGGTCCCGCGCTGA

Antitoxin

Nucleotide

• Length: 423 bp

>AT202529 NZ_CP074606:c3723401-3722979 [Salmonella enterica subsp. enterica serovar Newport str.]
TTCACCACATTATTTACCCCTGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin