Detailed information of TA system TA202123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3602306..3602720
• Replicon: chromosome
• Accession: NZ_CP074428
• Organism: Salmonella sp. SJTUF14523

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: KFD69_RS17640
• Protein ID: WP_000994230.1
• Coordinates: 3602463..3602720 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3602306..3602638 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD69_RS17600	3597567..3598064	-	498	WP_016695185.1	Saf-pilin pilus formation protein	-
KFD69_RS17605	3598827..3599397	-	571	Protein_3461	integrase core domain-containing protein	-
KFD69_RS17610	3599318..3599527	-	210	WP_001676010.1	hypothetical protein	-
KFD69_RS17615	3599580..3599894	+	315	WP_072100769.1	SymE family type I addiction module toxin	-
KFD69_RS17620	3599961..3600239	-	279	WP_012543321.1	hypothetical protein	-
KFD69_RS17625	3600556..3601023	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
KFD69_RS17630	3601020..3601337	-	318	WP_001751277.1	hypothetical protein	-
KFD69_RS17635	3601895..3602128	-	234	WP_124084119.1	hypothetical protein	-
-	3602306..3602638	-	333	-	-	Antitoxin
KFD69_RS17640	3602463..3602720	+	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
KFD69_RS17645	3602786..3603232	-	447	WP_000171102.1	hypothetical protein	-
KFD69_RS17650	3603229..3606603	-	3375	Protein_3470	RHS repeat-associated core domain-containing protein	-
KFD69_RS17655	3606603..3607109	-	507	Protein_3471	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3589671..3606525	16854
	-	flank	IS/Tn	-	-	3598827..3599105	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T202123 WP_000994230.1 NZ_CP074428:3602463-3602720 [Salmonella sp. SJTUF14523]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T202123 NZ_CP099318:c4664073-4663702 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Nucleotide

• Length: 333 bp

>AT202123 NZ_CP074428:c3602638-3602306 [Salmonella sp. SJTUF14523]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin