Detailed information of TA system TA202088

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3601740..3602154
• Replicon: chromosome
• Accession: NZ_CP074425
• Organism: Salmonella sp. SJTUF15034

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: KFD68_RS17640
• Protein ID: WP_000994230.1
• Coordinates: 3601897..3602154 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3601740..3602072 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD68_RS17600	3597001..3597498	-	498	WP_016695185.1	Saf-pilin pilus formation protein	-
KFD68_RS17605	3598261..3598831	-	571	Protein_3462	integrase core domain-containing protein	-
KFD68_RS17610	3598752..3598961	-	210	WP_001676010.1	hypothetical protein	-
KFD68_RS17615	3599014..3599328	+	315	WP_072100769.1	SymE family type I addiction module toxin	-
KFD68_RS17620	3599395..3599673	-	279	WP_012543321.1	hypothetical protein	-
KFD68_RS17625	3599990..3600457	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
KFD68_RS17630	3600454..3600771	-	318	WP_001751277.1	hypothetical protein	-
KFD68_RS17635	3601329..3601562	-	234	WP_124084119.1	hypothetical protein	-
-	3601740..3602072	-	333	-	-	Antitoxin
KFD68_RS17640	3601897..3602154	+	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
KFD68_RS17645	3602220..3602666	-	447	WP_000171102.1	hypothetical protein	-
KFD68_RS17650	3602663..3606037	-	3375	Protein_3471	RHS repeat-associated core domain-containing protein	-
KFD68_RS17655	3606037..3606543	-	507	Protein_3472	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3589105..3605959	16854
	-	flank	IS/Tn	-	-	3598261..3598539	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T202088 WP_000994230.1 NZ_CP074425:3601897-3602154 [Salmonella sp. SJTUF15034]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

>T202088 NZ_CP099310:c2822605-2822502 [Enterobacter ludwigii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 333 bp

>AT202088 NZ_CP074425:c3602072-3601740 [Salmonella sp. SJTUF15034]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin