Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) TglT-TakA/AbiEii-AbiEi
Location 1167057..1168558 Replicon chromosome
Accession NZ_CP072761
Organism Mycobacterium tuberculosis strain CG24

Toxin (Protein)


Gene name tglT Uniprot ID L7N4P5
Locus tag J8670_RS05500 Protein ID WP_003898703.1
Coordinates 1167677..1168558 (+) Length 294 a.a.

Antitoxin (Protein)


Gene name takA Uniprot ID L7N5C7
Locus tag J8670_RS05495 Protein ID WP_003405517.1
Coordinates 1167057..1167680 (+) Length 208 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8670_RS05475 (J8670_05475) 1162553..1163380 - 828 WP_003405370.1 PE domain-containing protein -
J8670_RS05480 (J8670_05480) 1164168..1164407 - 240 WP_009936438.1 hypothetical protein -
J8670_RS05485 (J8670_05485) 1164576..1165503 - 928 Protein_1096 IS5-like element ISMt1 family transposase -
J8670_RS05490 (J8670_05490) 1165785..1166810 - 1026 WP_003405514.1 serine protease -
J8670_RS05495 (J8670_05495) 1167057..1167680 + 624 WP_003405517.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
J8670_RS05500 (J8670_05500) 1167677..1168558 + 882 WP_003898703.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
J8670_RS05505 (J8670_05505) 1169428..1170675 + 1248 WP_003901078.1 IS256-like element IS1081 family transposase -
J8670_RS05510 (J8670_05510) 1171043..1172158 - 1116 WP_003405582.1 hypothetical protein -
J8670_RS05515 (J8670_05515) 1172115..1172318 - 204 WP_003405585.1 hypothetical protein -
J8670_RS05520 (J8670_05520) 1172391..1172837 + 447 WP_003405595.1 oxidation-sensing regulator MosR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - esxN 1158922..1170675 11753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 294 a.a.        Molecular weight: 31958.65 Da        Isoelectric Point: 6.3901

>T198399 WP_003898703.1 NZ_CP072761:1167677-1168558 [Mycobacterium tuberculosis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR

Download         Length: 882 bp

>T198399 NZ_CP096846:2232719-2233117 [Mycobacterium tuberculosis variant bovis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 208 a.a.        Molecular weight: 22531.68 Da        Isoelectric Point: 10.0518

>AT198399 WP_003405517.1 NZ_CP072761:1167057-1167680 [Mycobacterium tuberculosis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA

Download         Length: 624 bp

>AT198399 NZ_CP096846:2232491-2232718 [Mycobacterium tuberculosis variant bovis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7C46
PDB 6J7S
PDB 6J7T
PDB 7C48
PDB 6J7P
PDB 6J7Q
PDB 6Y5U
PDB 6J7O
PDB 6J7R
PDB 6J7N

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BT71

References