Detailed information of TA system TA197331

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2743133..2743347
• Replicon: chromosome
• Accession: NZ_CP072118
• Organism: Clostridioides difficile isolate MAR286

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: J6L80_RS12690
• Protein ID: WP_003429855.1
• Coordinates: 2743186..2743347 (-)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	2743133..2743266 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6L80_RS12675 (J6L80_12675)	2738867..2739070	+	204	WP_021369176.1	helix-turn-helix transcriptional regulator	-
J6L80_RS12680 (J6L80_12680)	2740065..2740862	-	798	WP_217598213.1	ORF6N domain-containing protein	-
J6L80_RS12685 (J6L80_12685)	2741140..2741352	+	213	WP_021377386.1	helix-turn-helix transcriptional regulator	-
-	2743133..2743266	+	134	-	-	Antitoxin
J6L80_RS12690 (J6L80_12690)	2743186..2743347	-	162	WP_003429855.1	hypothetical protein	Toxin
J6L80_RS12695 (J6L80_12695)	2743688..2744128	-	441	WP_003429853.1	phage portal protein	-
J6L80_RS12700 (J6L80_12700)	2744200..2744670	-	471	WP_003429851.1	phage tail tube protein	-
J6L80_RS12705 (J6L80_12705)	2744687..2745997	-	1311	WP_070116964.1	phage tail sheath family protein	-
J6L80_RS12710 (J6L80_12710)	2745998..2746174	-	177	WP_070112848.1	hypothetical protein	-
J6L80_RS12715 (J6L80_12715)	2746167..2746604	-	438	WP_003433544.1	hypothetical protein	-
J6L80_RS12720 (J6L80_12720)	2746597..2747022	-	426	WP_038812299.1	HK97 gp10 family phage protein	-
J6L80_RS12725 (J6L80_12725)	2747022..2747369	-	348	WP_070113072.1	hypothetical protein	-
J6L80_RS12730 (J6L80_12730)	2747363..2747764	-	402	WP_021363493.1	hypothetical protein	-
J6L80_RS12735 (J6L80_12735)	2747774..2748007	-	234	WP_070113070.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2706954..2776195	69241

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T197331 WP_003429855.1 NZ_CP072118:c2743347-2743186 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T197331 NZ_CP096017:2229826-2230116 [Alkalimarinus coralli]
ATGATCATTTCCTTTGGCAATAAAGCGACATCAGACCTGTTTAATGGTGTTTCTAGTCGTTGGGTGCGAAAGCTGCCTAA
TCAGATACATGAGTTGGCCTTGTATAAGCTTGATGTTATCAATGCTGCTCAAAACCTTGATGACCTTAAGTCGCCTCCTG
GAAATAGACTTGAGCTGCTCAAAGGTGACTTAGAAGGTTTCCATAGTATTCGTATTAATTCTCAGTGGCGTATTGTATTT
CGCTGGGATTCTAATGCAGCTCATGATGTTCAAATAGTGGATTACCACTAA

Antitoxin

Nucleotide

• Length: 134 bp

>AT197331 NZ_CP072118:2743133-2743266 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin