Detailed information of TA system TA197328

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1687382..1687591
• Replicon: chromosome
• Accession: NZ_CP072118
• Organism: Clostridioides difficile isolate MAR286

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: J6L80_RS07855
• Protein ID: WP_003431040.1
• Coordinates: 1687382..1687540 (+)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	1687457..1687591 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6L80_RS07820 (J6L80_07820)	1682697..1683080	+	384	WP_071599195.1	helix-turn-helix transcriptional regulator	-
J6L80_RS07825 (J6L80_07825)	1683179..1683847	+	669	WP_003431044.1	VanZ family protein	-
J6L80_RS07830 (J6L80_07830)	1683887..1683967	+	81	Protein_1453	VOC family protein	-
J6L80_RS07835 (J6L80_07835)	1684330..1684455	-	126	WP_003431043.1	hypothetical protein	-
J6L80_RS07840 (J6L80_07840)	1684833..1685255	-	423	WP_003431042.1	N-terminal phage integrase SAM-like domain-containing protein	-
J6L80_RS07850 (J6L80_07850)	1685654..1687024	+	1371	WP_003431041.1	cell wall-binding protein Cwp29	-
J6L80_RS07855 (J6L80_07855)	1687382..1687540	+	159	WP_003431040.1	hypothetical protein	Toxin
-	1687457..1687591	-	135	-	-	Antitoxin
J6L80_RS07860 (J6L80_07860)	1688410..1688670	+	261	WP_003431039.1	phage holin family protein	-
J6L80_RS07865 (J6L80_07865)	1688667..1689464	+	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
J6L80_RS07870 (J6L80_07870)	1689486..1689647	-	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
J6L80_RS07875 (J6L80_07875)	1689665..1690246	-	582	WP_003431036.1	accessory gene regulator B family protein	-
J6L80_RS07880 (J6L80_07880)	1690289..1691611	-	1323	WP_021427477.1	ATP-binding protein	-
J6L80_RS07885 (J6L80_07885)	1692057..1692257	-	201	WP_003431034.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1684833..1693422	8589

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T197328 WP_003431040.1 NZ_CP072118:1687382-1687540 [Clostridioides difficile]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T197328 NZ_CP096017:c1200492-1200181 [Alkalimarinus coralli]
ATGGCTCAAATAATCTGGACTGAGCCCGCACTAAATGATTTGAACGATATTGCTGAGTATATTGCGGTCAGCAATCCGTA
TGCAGCTAAACAACTAGTAGAAAACGTTTTCAGCAATGTCCAGAGACTAGAACAATTTCCAGATTCAGGCAGAGTACCTG
ATGAGATTTCGAATCTAAATTACCGAGAAGTTGTAGTAAACCCTTGCCGTGTTTTTTACAAAATTGACATGGATTCGGTG
TATATCCTTCATGTGATGAGACAAGAAAGGGATTTAAGGAAGTTCTTACTGTCTACCACAAATGGAAGCTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT197328 NZ_CP072118:c1687591-1687457 [Clostridioides difficile]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin